TAPI-2
|
3物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 1mg
- 5mg
- 10mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TRCH791950
- 製品説明
- 英語製品説明N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid
- 包装単位1mg
- 価格￥69600
- 更新しました2023-06-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TRCH791950
- 製品説明
- 英語製品説明N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid
- 包装単位5mg
- 価格￥297000
- 更新しました2023-06-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TRCH791950
- 製品説明
- 英語製品説明N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid
- 包装単位10mg
- 価格￥527500
- 更新しました2023-06-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TRCH791950 | N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid |
1mg | ￥69600 | 2023-06-01 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TRCH791950 | N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid |
5mg | ￥297000 | 2023-06-01 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TRCH791950 | N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid |
10mg | ￥527500 | 2023-06-01 | 購入 |
プロパティ
比重(密度) :1.127±0.06 g/cm3(Predicted)
貯蔵温度 :Store at -20°C
溶解性 :Ethanol: 5 mg/ml; Water: 8 mg/ml
外見 :Solid
酸解離定数(Pka) :9.17±0.20(Predicted)
色 :White to off-white
Sensitive :Light Sensitive & Hygroscopic
貯蔵温度 :Store at -20°C
溶解性 :Ethanol: 5 mg/ml; Water: 8 mg/ml
外見 :Solid
酸解離定数(Pka) :9.17±0.20(Predicted)
色 :White to off-white
Sensitive :Light Sensitive & Hygroscopic
安全情報
| 絵表示(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| 注意喚起語: | ||||||||
| 危険有害性情報: |
|
|||||||
| 注意書き: |
|
説明
The extracellular domains of many different types of transmembrane proteins, including growth factors, growth factor receptors and cell adhesion molecules, are proteolytically released (shed) in response to environmental cues. TNF protease inhibitor 2 (TAPI-2) is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE), other ADAMs (a disintegrin and metalloproteinases), and other matrix metalloproteinases. It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit, with an IC50 value of 10 μM. TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 μM, respectively. In T4-2 breast cancer cells, 20 μM TAPI-2 prevented mobilization of the growth factors TGF-α and amphiregulin leading to reversion of the malignant cellular phenotype.関連製品価格
グリシル-L-アラニン関連商品価格
- グリシル-L-アラニン
￥5000-1219000