VU 0360223
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- $32 - $1211
- Product name: VU 0360223
- CAS: 1274859-33-4
- MF: C15H9FN2S
- MW: 268.31
- EINECS:
- MDL Number:MFCD20926362
- Synonyms:VU 0360223;3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile;3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile;Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-
10 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- TRC
- Usbiological
Package
- 1mg
- 5MG
- 10mg
- 50mg
- ManufacturerAK Scientific
- Product number7746DF
- Product description3-Fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0009794
- Product descriptionVU-0360223 95.00%
- Packaging5MG
- Price$512
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5574
- Product descriptionVU0360223
- Packaging10mg
- Price$291
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5574
- Product descriptionVU0360223
- Packaging50mg
- Price$1211
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11995
- Product descriptionVU0360223 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11995
- Product descriptionVU0360223 ≥98%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11995
- Product descriptionVU0360223 ≥98%
- Packaging10mg
- Price$130
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11995
- Product descriptionVU0360223 ≥98%
- Packaging50mg
- Price$517
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberV787580
- Product descriptionVU0360223
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number257063
- Product descriptionVU 0360223
- Packaging10mg
- Price$446
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 7746DF | 3-Fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile | 1mg | $133 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009794 | VU-0360223 95.00% | 5MG | $512 | 2021-12-16 | Buy |
| ApexBio Technology | B5574 | VU0360223 | 10mg | $291 | 2021-12-16 | Buy |
| ApexBio Technology | B5574 | VU0360223 | 50mg | $1211 | 2021-12-16 | Buy |
| Cayman Chemical | 11995 | VU0360223 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11995 | VU0360223 ≥98% | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 11995 | VU0360223 ≥98% | 10mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 11995 | VU0360223 ≥98% | 50mg | $517 | 2024-03-01 | Buy |
| TRC | V787580 | VU0360223 | 5mg | $65 | 2021-12-16 | Buy |
| Usbiological | 257063 | VU 0360223 | 10mg | $446 | 2021-12-16 | Buy |
Properties
Boiling point :434.9±35.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :Soluble to 25 mM in DMSO
form :Powder
pka :1.10±0.10(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :Soluble to 25 mM in DMSO
form :Powder
pka :1.10±0.10(Predicted)
Safety Information
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Description
Glutamate, the major excitatory neurotransmitter in the central nervous system, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors (mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson’s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. VU0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 that demonstrates an IC50 value of 61 nM in a calcium mobilization assay and a Ki value of 477 nM in a radioligand binding assay. A 10 μM concentration of VU0360223 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of VU0360223 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.More related product prices
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