ceralifimod
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- $32 - $3720
- Product name: ceralifimod
- CAS: 891859-12-4
- MF: C27H33NO4
- MW: 435.56
- EINECS:
- MDL Number:MFCD28502037
- Synonyms:ceralifimod;Ceralifimod (Synonyms: ONO-4641);ONO-4641;3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-;Ceralifimod (ONO-4641)
10 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Crysdot
- Tocris
Package
- 5mg
- 10
- 1mg
- 10mg
- 25mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number8625CS
- Product descriptionCeralifimod
- Packaging5mg
- Price$201
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8625CS
- Product descriptionCeralifimod
- Packaging25mg
- Price$437
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number24159
- Product descriptionCeralifimod ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24159
- Product descriptionCeralifimod ≥95%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24159
- Product descriptionCeralifimod ≥95%
- Packaging10mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24159
- Product descriptionCeralifimod ≥95%
- Packaging25mg
- Price$305
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD11027862
- Product descriptionCeralifimod 95+%
- Packaging100mg
- Price$743
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD11027862
- Product descriptionCeralifimod 95+%
- Packaging250mg
- Price$1488
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD11027862
- Product descriptionCeralifimod 95+%
- Packaging1g
- Price$3720
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6690
- Product descriptionCeralifimod ≥95%(HPLC)
- Packaging10
- Price$123
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8625CS | Ceralifimod | 5mg | $201 | 2021-12-16 | Buy |
| AK Scientific | 8625CS | Ceralifimod | 25mg | $437 | 2021-12-16 | Buy |
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 10mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 25mg | $305 | 2024-03-01 | Buy |
| Crysdot | CD11027862 | Ceralifimod 95+% | 100mg | $743 | 2021-12-16 | Buy |
| Crysdot | CD11027862 | Ceralifimod 95+% | 250mg | $1488 | 2021-12-16 | Buy |
| Crysdot | CD11027862 | Ceralifimod 95+% | 1g | $3720 | 2021-12-16 | Buy |
| Tocris | 6690 | Ceralifimod ≥95%(HPLC) | 10 | $123 | 2021-12-16 | Buy |
Properties
Boiling point :595.9±50.0 °C(Predicted)
Density :1.172±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM)
form :A crystalline solid
pka :2.71±0.20(Predicted)
color :White to off-white
Density :1.172±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM)
form :A crystalline solid
pka :2.71±0.20(Predicted)
color :White to off-white
Safety Information
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Description
Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). It is selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively). In vivo, ceralifimod (0.03 and 0.1 mg/kg) reduces paw edema in a rat model of collagen induced arthritis (CIA). It also delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of experimental autoimmune encephalomyelitis (EAE) and prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE.Suppliers and manufacturers
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