GSK 2830371
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- $32 - $1900
- Product name: GSK 2830371
- CAS: 1404456-53-6
- MF: C23H29ClN4O2S
- MW: 461.02
- EINECS:
- MDL Number:MFCD28009442
- Synonyms:GSK 2830371;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide;(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide;GSK 2830371 USP/EP/BP;2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide;GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide;GSK 2830371, 10 mM in DMSO
25 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 1mg
- 10mg
- 10
- 5mg
- 25mg
- 50
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5055
- Product descriptionGSK2830371
- Packaging50mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA447126
- Product descriptionGsk2830371 98+%
- Packaging5mg
- Price$76
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1169
- Product descriptionGSK2830371
- Packaging100mg
- Price$819
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16973
- Product descriptionGSK2830371 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16973
- Product descriptionGSK2830371 ≥98%
- Packaging5mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16973
- Product descriptionGSK2830371 ≥98%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16973
- Product descriptionGSK2830371 ≥98%
- Packaging25mg
- Price$381
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM176427
- Product description(S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide 98%
- Packaging100mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2126
- Product descriptionGSK2830371 98.94%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2126
- Product descriptionGSK2830371 98.94%
- Packaging10mg
- Price$102
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2126
- Product descriptionGSK2830371 98.94%
- Packaging50mg
- Price$324
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2126
- Product descriptionGSK2830371 98.94%
- Packaging100mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2126
- Product descriptionGSK2830371 98.94%
- Packaging200mg
- Price$792
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003601
- Product descriptionGSK2830371 98+%
- Packaging5mg
- Price$46
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003601
- Product descriptionGSK2830371 98+%
- Packaging10mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003601
- Product descriptionGSK2830371 98+%
- Packaging50mg
- Price$224
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5055 | GSK2830371 | 50mg | $550 | 2021-12-16 | Buy |
| Ambeed | A447126 | Gsk2830371 98+% | 5mg | $76 | 2021-12-16 | Buy |
| ApexBio Technology | B1169 | GSK2830371 | 100mg | $819 | 2021-12-16 | Buy |
| Cayman Chemical | 16973 | GSK2830371 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16973 | GSK2830371 ≥98% | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 16973 | GSK2830371 ≥98% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 16973 | GSK2830371 ≥98% | 25mg | $381 | 2024-03-01 | Buy |
| Chemenu | CM176427 | (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide 98% | 100mg | $340 | 2021-12-16 | Buy |
| ChemScene | CS-2126 | GSK2830371 98.94% | 5mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-2126 | GSK2830371 98.94% | 10mg | $102 | 2021-12-16 | Buy |
| ChemScene | CS-2126 | GSK2830371 98.94% | 50mg | $324 | 2021-12-16 | Buy |
| ChemScene | CS-2126 | GSK2830371 98.94% | 100mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-2126 | GSK2830371 98.94% | 200mg | $792 | 2021-12-16 | Buy |
| Crysdot | CD31003601 | GSK2830371 98+% | 5mg | $46 | 2021-12-16 | Buy |
| Crysdot | CD31003601 | GSK2830371 98+% | 10mg | $67 | 2021-12-16 | Buy |
| Crysdot | CD31003601 | GSK2830371 98+% | 50mg | $224 | 2021-12-16 | Buy |
Properties
Boiling point :704.1±60.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :13.29±0.46(Predicted)
form :powder
color :white to beige
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :13.29±0.46(Predicted)
form :powder
color :white to beige
Safety Information
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Description
The wild-type p53-induced phosphatase Wip1, also known as protein phosphatase magnesium-dependent 1 delta (PPM1D) or PP2Cδ, modulates cell cycling and may contribute to some forms of cancer. GSK2830371 is a potent inhibitor of Wip1 (IC50 = 6 nM). It displays selectivity for Wip1 over 21 other phosphatases. GSK2830371 increases phosphorylation of Wip1 substrates and blocks cell cycling in hematopoietic cancer cells and in Wip1-amplified cancer cells with wild-type p53. This compound is orally bioavailable and causes inhibition of lymphoma xenograft growth in mice.Related product price
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