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ChemicalBook >> CAS DataBase List >> MIRA-1

MIRA-1

MIRA-1 price.
  • $52 - $763
  • Product name: MIRA-1
  • CAS: 72835-26-8
  • MF: C8H9NO4
  • MW: 183.16
  • EINECS:-0
  • MDL Number:MFCD12828765
  • Synonyms:MIRA-1;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione;NSC 19630;1H-Pyrrole-2,5-dione, 1-[(1-oxopropoxy)methyl]-;Ethyl 2,5-Dioxo-2,5-dihydropyrrole-1-acetate;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2;5-dihydro-1H-pyrrol-1-yl)methyl propionate;p53 Activator VIII
Price14 Properties Safety Information Description
14 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5MG
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3962CB
  • Product description1h-Pyrrole-2,5-dione,1-[(1-oxopropoxy)methyl]-
  • Packaging10mg
  • Price$197
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1208571
  • Product description(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97%
  • Packaging100mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1208571
  • Product description(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97%
  • Packaging250mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1208571
  • Product description(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97%
  • Packaging1g
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008055
  • Product descriptionMIRA-1 95.00%
  • Packaging5MG
  • Price$496.93
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4479
  • Product descriptionMIRA-1
  • Packaging10mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4479
  • Product descriptionMIRA-1
  • Packaging50mg
  • Price$763
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14858
  • Product descriptionMIRA-1 ≥98%
  • Packaging10mg
  • Price$106
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14858
  • Product descriptionMIRA-1 ≥98%
  • Packaging50mg
  • Price$440
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number681647
  • Product descriptionWRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem
  • Packaging5MG
  • Price$144
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number3362
  • Product descriptionMIRA-1
  • Packaging10
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberN900430
  • Product descriptionMIRA-1
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberN900430
  • Product descriptionMIRA-1
  • Packaging50mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number255822
  • Product descriptionMIRA-1
  • Packaging10mg
  • Price$366
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3962CB 1h-Pyrrole-2,5-dione,1-[(1-oxopropoxy)methyl]- 10mg $197 2021-12-16 Buy
Ambeed A1208571 (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97% 100mg $52 2021-12-16 Buy
Ambeed A1208571 (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97% 250mg $87 2021-12-16 Buy
Ambeed A1208571 (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97% 1g $208 2021-12-16 Buy
American Custom Chemicals Corporation API0008055 MIRA-1 95.00% 5MG $496.93 2021-12-16 Buy
ApexBio Technology A4479 MIRA-1 10mg $182 2021-12-16 Buy
ApexBio Technology A4479 MIRA-1 50mg $763 2021-12-16 Buy
Cayman Chemical 14858 MIRA-1 ≥98% 10mg $106 2024-03-01 Buy
Cayman Chemical 14858 MIRA-1 ≥98% 50mg $440 2024-03-01 Buy
Sigma-Aldrich 681647 WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem 5MG $144 2024-03-01 Buy
Tocris 3362 MIRA-1 10 $119 2021-12-16 Buy
TRC N900430 MIRA-1 10mg $60 2021-12-16 Buy
TRC N900430 MIRA-1 50mg $320 2021-12-16 Buy
Usbiological 255822 MIRA-1 10mg $366 2021-12-16 Buy

Properties

Melting point :44 °C
Boiling point :298.2±23.0 °C(Predicted)
Density :1.307±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble to 100 mM in DMSO and to 100 mM in ethanol
form :Powder
pka :-2.79±0.20(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 μM in vitro). Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.

Suppliers and manufacturers

TargetMol Chemicals Inc.
MIRA-1
$34.00 /2mg
MIRA-1 CAS:72835-26-8
Aladdin Scientific
Suzhou ARTK Medchem Co., Ltd. 3B Pharmachem (Wuhan) International Co.,Ltd. VDM Biochemicals Shanghai Raise Chemical Technology Co.,Ltd Bide Pharmatech Ltd. EMMX Biotechnology LLC SHANGHAI FDC-CHEMICAL CO.,LTD Henan Weituxi Chemical Technology Co., Ltd.