PF-03814735
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- $37 - $1126
- Product name: PF-03814735
- CAS: 942487-16-3
- MF: C23H25F3N6O2
- MW: 474.48
- EINECS:-0
- MDL Number:MFCD16659065
- Synonyms:PF-03814735;N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide;Acetamide, N-[2-[(1S,4R)-6-[[4-(cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-;RYYNGWLOYLRZLK-RBUKOAKNSA-N;CS-240;PF-03814735 USP/EP/BP;Abecarnil Impurity 3;PF-03814735 PF03814735
25 prices
Selected condition:
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number2639AH
- Product descriptionN-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide
- Packaging50mg
- Price$927
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4128
- Product descriptionPF-03814735
- Packaging5mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4128
- Product descriptionPF-03814735
- Packaging10mg
- Price$372
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4128
- Product descriptionPF-03814735
- Packaging50mg
- Price$1126
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2023
- Product descriptionPF03814735 98%
- Packaging5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15015
- Product descriptionPF-03814735 ≥95%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15015
- Product descriptionPF-03814735 ≥95%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15015
- Product descriptionPF-03814735 ≥95%
- Packaging10mg
- Price$213
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15015
- Product descriptionPF-03814735 ≥95%
- Packaging50mg
- Price$793
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM141482
- Product descriptionN-(2-((1S,4R)-6-((4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide 98%
- Packaging50mg
- Price$468
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0684
- Product descriptionPF-03814735 99.82%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0684
- Product descriptionPF-03814735 99.82%
- Packaging10mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0684
- Product descriptionPF-03814735 99.82%
- Packaging50mg
- Price$720
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000141
- Product descriptionPF-03814735 98+%
- Packaging50mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000141
- Product descriptionPF-03814735 98+%
- Packaging10mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000141
- Product descriptionPF-03814735 98+%
- Packaging5mg
- Price$88
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 2639AH | N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide | 50mg | $927 | 2021-12-16 | Buy |
ApexBio Technology | A4128 | PF-03814735 | 5mg | $197 | 2021-12-16 | Buy |
ApexBio Technology | A4128 | PF-03814735 | 10mg | $372 | 2021-12-16 | Buy |
ApexBio Technology | A4128 | PF-03814735 | 50mg | $1126 | 2021-12-16 | Buy |
Axon Medchem | Axon2023 | PF03814735 98% | 5mg | $132 | 2021-12-16 | Buy |
Cayman Chemical | 15015 | PF-03814735 ≥95% | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 15015 | PF-03814735 ≥95% | 5mg | $116 | 2024-03-01 | Buy |
Cayman Chemical | 15015 | PF-03814735 ≥95% | 10mg | $213 | 2024-03-01 | Buy |
Cayman Chemical | 15015 | PF-03814735 ≥95% | 50mg | $793 | 2024-03-01 | Buy |
Chemenu | CM141482 | N-(2-((1S,4R)-6-((4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide 98% | 50mg | $468 | 2021-12-16 | Buy |
ChemScene | CS-0684 | PF-03814735 99.82% | 5mg | $120 | 2021-12-16 | Buy |
ChemScene | CS-0684 | PF-03814735 99.82% | 10mg | $216 | 2021-12-16 | Buy |
ChemScene | CS-0684 | PF-03814735 99.82% | 50mg | $720 | 2021-12-16 | Buy |
Crysdot | CD31000141 | PF-03814735 98+% | 50mg | $500 | 2021-12-16 | Buy |
Crysdot | CD31000141 | PF-03814735 98+% | 10mg | $165 | 2021-12-16 | Buy |
Crysdot | CD31000141 | PF-03814735 98+% | 5mg | $88 | 2021-12-16 | Buy |
Properties
Melting point :181-183°C
Density :1.443
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :15.02±0.46(Predicted)
color :white to beige
Density :1.443
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :15.02±0.46(Predicted)
color :white to beige
Safety Information
Symbol(GHS): |
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Description
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.Related product price
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