trans-Ned 19
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- $44 - $1135
- Product name: trans-Ned 19
- CAS: 1354235-96-3
- MF: C30H31FN4O3
- MW: 514.59
- EINECS:
- MDL Number:MFCD20926336
- Synonyms:trans-Ned 19;(1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]Methyl]-4-Methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid;(1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid;1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-, (1R,3S)-;transNed 19,trans Ned 19
13 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10
- 0.5MG
- 10MG
- 50mg
- ManufacturerAK Scientific
- Product numberSYN5547
- Product descriptionNed-19
- Packaging50mg
- Price$1055
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010253
- Product description(1R,3S)-1-[3-[[4-(2-FLUOROPHENYL)PIPERAZIN-1-YL]METHYL]-4-METHOXYPHENYL]-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID 95.00%
- Packaging10MG
- Price$891.38
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010253
- Product description(1R,3S)-1-[3-[[4-(2-FLUOROPHENYL)PIPERAZIN-1-YL]METHYL]-4-METHOXYPHENYL]-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID 95.00%
- Packaging0.5MG
- Price$351
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17527
- Product descriptiontrans-Ned-19 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17527
- Product descriptiontrans-Ned-19 ≥98%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17527
- Product descriptiontrans-Ned-19 ≥98%
- Packaging10mg
- Price$321
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0027606
- Product descriptiontrans-Ned19 99.53%
- Packaging5mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0027606
- Product descriptiontrans-Ned19 99.53%
- Packaging10mg
- Price$295
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0027606
- Product descriptiontrans-Ned19 99.53%
- Packaging50mg
- Price$1050
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number52484
- Product descriptiontrans-Ned-19
- Packaging5mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number3954
- Product descriptiontrans-Ned19 ≥98%(HPLC)
- Packaging10
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberN388750
- Product descriptiontrans-Ned-19
- Packaging50mg
- Price$1135
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256960
- Product descriptiontrans-Ned 19
- Packaging10mg
- Price$616
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5547 | Ned-19 | 50mg | $1055 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010253 | (1R,3S)-1-[3-[[4-(2-FLUOROPHENYL)PIPERAZIN-1-YL]METHYL]-4-METHOXYPHENYL]-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID 95.00% | 10MG | $891.38 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010253 | (1R,3S)-1-[3-[[4-(2-FLUOROPHENYL)PIPERAZIN-1-YL]METHYL]-4-METHOXYPHENYL]-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID 95.00% | 0.5MG | $351 | 2021-12-16 | Buy |
| Cayman Chemical | 17527 | trans-Ned-19 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17527 | trans-Ned-19 ≥98% | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 17527 | trans-Ned-19 ≥98% | 10mg | $321 | 2024-03-01 | Buy |
| ChemScene | CS-0027606 | trans-Ned19 99.53% | 5mg | $195 | 2021-12-16 | Buy |
| ChemScene | CS-0027606 | trans-Ned19 99.53% | 10mg | $295 | 2021-12-16 | Buy |
| ChemScene | CS-0027606 | trans-Ned19 99.53% | 50mg | $1050 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 52484 | trans-Ned-19 | 5mg | $650 | 2021-12-16 | Buy |
| Tocris | 3954 | trans-Ned19 ≥98%(HPLC) | 10 | $335 | 2021-12-16 | Buy |
| TRC | N388750 | trans-Ned-19 | 50mg | $1135 | 2021-12-16 | Buy |
| Usbiological | 256960 | trans-Ned 19 | 10mg | $616 | 2021-12-16 | Buy |
Properties
Melting point :168-173°C
Boiling point :715.1±60.0 °C(Predicted)
Density :1.316±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Methanol
form :Solid
pka :2.17±0.40(Predicted)
color :Yellow
Boiling point :715.1±60.0 °C(Predicted)
Density :1.316±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Methanol
form :Solid
pka :2.17±0.40(Predicted)
color :Yellow
Safety Information
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Description
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a dinucleotide second messenger that triggers the release of calcium from lysosomes and related cellular compartments. trans-Ned-19 is a structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM). The trans form of Ned-19 is significantly more potent than the cis isomer in both assays. Ned-19 does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release. It directly binds NAADP receptors on lysosomes in mouse pancreatic beta cells and competitively antagonizes activation by NAADP. It inhibits glucose-induced calcium oscillations in pancreatic islets and insulin-induced calcium increases in 3T3-L1 adipocytes. Ned-19 also blocks calcium signaling induced by endothelin-1 or norepinephrine in renal afferent arterioles. Ned-19 dose-dependently reduces infection of host cells by Ebola virus.Suppliers and manufacturers
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
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TargetMol Chemicals Inc.
J & K SCIENTIFIC LTD.
Chemsky（shanghai）International Co.,Ltd.
Shanghai TaoSu Biochemical Technology Co., Ltd.
EMMX Biotechnology LLC
Shanghai EFE Biological Technology Co., Ltd.
