[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
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2物価
選択条件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番号SML0521
- 製品説明 ≥98% (HPLC)
- 英語製品説明ML 210 ≥98% (HPLC)
- 包装単位5mg
- 価格￥25600
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号SML0521
- 製品説明 ≥98% (HPLC)
- 英語製品説明ML 210 ≥98% (HPLC)
- 包装単位25mg
- 価格￥95700
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML0521 | ≥98% (HPLC) ML 210 ≥98% (HPLC) |
5mg | ￥25600 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | SML0521 | ≥98% (HPLC) ML 210 ≥98% (HPLC) |
25mg | ￥95700 | 2024-03-01 | 購入 |
プロパティ
沸点 :644.7±55.0 °C(Predicted)
比重(密度) :1.415±0.06 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :Soluble in DMSO (up to 30 mg/ml)
酸解離定数(Pka) :4.69±0.10(Predicted)
外見 :powder
色 :white to beige
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
比重(密度) :1.415±0.06 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :Soluble in DMSO (up to 30 mg/ml)
酸解離定数(Pka) :4.69±0.10(Predicted)
外見 :powder
色 :white to beige
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
安全情報
| 絵表示(GHS): |
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| 注意喚起語: | Warning | ||||||||||||||
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説明
ML210 (CAS 1360705-96-9) is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50?= 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50?= 272 nM for BJeH-LT (non-HRAS expressing) cells.1?ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3?Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3関連製品価格
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