(2R)-Octyl-α-hydroxyglutarate
2物価
選択条件:
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番号SML2200
- 製品説明オクチル-(R)-2HG ≥98% (HPLC)
- 英語製品説明Octyl-(R)-2HG ≥98% (HPLC)
- 包装単位5mg
- 価格¥25800
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号SML2200
- 製品説明オクチル-(R)-2HG ≥98% (HPLC)
- 英語製品説明Octyl-(R)-2HG ≥98% (HPLC)
- 包装単位25mg
- 価格¥104000
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
Sigma-Aldrich Japan | SML2200 | オクチル-(R)-2HG ≥98% (HPLC) Octyl-(R)-2HG ≥98% (HPLC) |
5mg | ¥25800 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | SML2200 | オクチル-(R)-2HG ≥98% (HPLC) Octyl-(R)-2HG ≥98% (HPLC) |
25mg | ¥104000 | 2024-03-01 | 購入 |
プロパティ
貯蔵温度 :-20°C
溶解性 :DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 1 mg/ml
外見 :powder
色 :white to beige
溶解性 :DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 1 mg/ml
外見 :powder
色 :white to beige
安全情報
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説明
α-Hydroxyglutaric acid (2-HG; ) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate. 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases. (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.供給者とメーカー
TargetMol Chemicals Inc.
Career Henan Chemica Co
Aladdin Scientific
Shanghai Carlow Chemicals Co., Ltd.
Sichuan Wei Keqi Biological Technology Co., Ltd.
JW & Y Pharmlab Co., Ltd.
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Beijing xinyanhui pharmaceutical research and development co., LTD
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Shanghai hongqu biomedical technology co. LTD