(2R)-Octyl-α-hydroxyglutarate
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- $54 - $6880
- Product name: (2R)-Octyl-α-hydroxyglutarate
- CAS: 1391194-67-4
- MF: C13H24O5
- MW: 260.33
- EINECS:
- MDL Number:MFCD30735809
- Synonyms:(2R)-Octyl-α-hydroxyglutarate;(R)-2-Hydroxy-pentanedioic acid 1-octyl ester;(2R)-2-Hydroxy-pentanedioic acid 1-octyl ester;(2R)-Octyl-.alpha.-hydroxyglutarate;(4R)-4-hydroxy-5-octoxy-5-oxopentanoic acid;Octyl-(R)-2HG;(2R)-Octyl-2-HG;Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2R)-
7 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number5661DV
- Product description(2R)-Octyl-alpha-hydroxyglutarate
- Packaging1mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16366
- Product description(2R)-Octyl-α-hydroxyglutarate ≥95%
- Packaging1mg
- Price$54
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16366
- Product description(2R)-Octyl-α-hydroxyglutarate ≥95%
- Packaging5mg
- Price$231
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16366
- Product description(2R)-Octyl-α-hydroxyglutarate ≥95%
- Packaging10mg
- Price$410
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML2200
- Product descriptionOctyl-(R)-2HG ≥98% (HPLC)
- Packaging5mg
- Price$131
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML2200
- Product descriptionOctyl-(R)-2HG ≥98% (HPLC)
- Packaging25mg
- Price$530
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberO287600
- Product description(2R)-Octyl-α-hydroxyglutarate
- Packaging25mg
- Price$840
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5661DV | (2R)-Octyl-alpha-hydroxyglutarate | 1mg | $156 | 2021-12-16 | Buy |
| Cayman Chemical | 16366 | (2R)-Octyl-α-hydroxyglutarate ≥95% | 1mg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 16366 | (2R)-Octyl-α-hydroxyglutarate ≥95% | 5mg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 16366 | (2R)-Octyl-α-hydroxyglutarate ≥95% | 10mg | $410 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2200 | Octyl-(R)-2HG ≥98% (HPLC) | 5mg | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2200 | Octyl-(R)-2HG ≥98% (HPLC) | 25mg | $530 | 2024-03-01 | Buy |
| TRC | O287600 | (2R)-Octyl-α-hydroxyglutarate | 25mg | $840 | 2021-12-16 | Buy |
Properties
storage temp. :-20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 1 mg/ml
form :powder
color :white to beige
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 1 mg/ml
form :powder
color :white to beige
Safety Information
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Description
α-Hydroxyglutaric acid (2-HG; ) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate. 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases. (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.Suppliers and manufacturers
TargetMol Chemicals Inc.
Career Henan Chemica Co
Aladdin Scientific
Beijing HwrkChemical Technology Co., Ltd
Shanghai Carlow Chemicals Co., Ltd.
Sichuan Wei Keqi Biological Technology Co., Ltd.
JW & Y Pharmlab Co., Ltd.
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Beijing xinyanhui pharmaceutical research and development co., LTD
