TER-199
|
- ￥140000 - ￥140000
- 化学名: TER-199
- 英語名: Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
- 別名:エチル (4S)-4-アミノ-4-{[(1R)-2-(ベンジルスルファニル)-1-{[(1R)-2-エトキシ-2-オキソ-1-フェニルエチル]カルバモイル}エチル]カルバモイル}ブタノアート;4-(エトキシカルボニル)-L-Abu-S-Bzl-L-Cys-D-フェニルGly-OEt;TER-199
- CAS番号: 168682-53-9
- 分子式: C27H35N3O6S
- 分子量: 529.65
- EINECS:-0
- MDL Number:MFCD27982957
1物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 100mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01COBQJ-7612
- 製品説明
- 英語製品説明Ezatiostat
- 包装単位100mg
- 価格￥140000
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01COBQJ-7612 | Ezatiostat |
100mg | ￥140000 | 2024-03-01 | 購入 |
プロパティ
融点 :>94°C (dec.)
沸点 :749.7±60.0 °C(Predicted)
比重(密度) :1.216±0.06 g/cm3(Predicted)
貯蔵温度 :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解性 :DMSO (Slightly), Methanol (Slightly)
酸解離定数(Pka) :12?+-.0.46(Predicted)
外見 :Solid
色 :White to Off-White
沸点 :749.7±60.0 °C(Predicted)
比重(密度) :1.216±0.06 g/cm3(Predicted)
貯蔵温度 :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解性 :DMSO (Slightly), Methanol (Slightly)
酸解離定数(Pka) :12?+-.0.46(Predicted)
外見 :Solid
色 :White to Off-White
安全情報
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説明
Glutathione S-transferases (GSTs) are ubiquitous multifunctional enzymes that play key roles in cellular detoxification and signal transduction by conjugating target substrates to glutathione. GSTP1-1, the most prevalent GST isozyme in nonhepatic tissues, binds to and inhibits the stress-activated c-Jun N-terminal kinase (JNK), an important regulator of cell proliferation, differentiation, and apoptosis. GSTP1-1 is overexpressed in many cancers and has been linked to drug resistance. Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity (Ki = 400 nM) with minimal effect on the related GSTα and -μ families (Kis range from 20-75 μM). After intracellular de-esterification, the active form of ezatiostat, TLK117, binds to and inhibits GSTP1-1, restoring JNK-mediated cellular proliferation and differentiation signaling pathways. Ezatiostat has been shown to stimulate the proliferation of myeloid precursors in preclinical models and is under clinical examination for its potential prevention of myelosuppression in myelodysplastic syndrome.関連製品価格
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