3-シアノ-7-エトキシクマリン
- ¥25000 - ¥116000
- 化学名: 3-シアノ-7-エトキシクマリン
- 英語名: 3-CYANO-7-ETHOXYCOUMARIN
- 別名:3-シアノ-7-エトキシクマリン;2-オキソ-7-エトキシ-2H-1-ベンゾピラン-3-カルボニトリル;7-エトキシ-2-オキソ-2H-クロメン-3-カルボニトリル
- CAS番号: 117620-77-6
- 分子式: C12H9NO3
- 分子量: 215.2
- EINECS:200-562-0
- MDL Number:MFCD00467359
4物価
選択条件:
ブランド
- 富士フイルム和光純薬株式会社(wako)
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 10mg
- 50mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC4815
- 製品説明
- 英語製品説明3-Cyano-7-ethoxycoumarin
- 包装単位10mg
- 価格¥25000
- 更新しました2021-03-23
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC4815
- 製品説明
- 英語製品説明3-Cyano-7-ethoxycoumarin
- 包装単位50mg
- 価格¥94000
- 更新しました2021-03-23
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号UC455
- 製品説明 ≥97% (HPLC)
- 英語製品説明3-Cyano-7-ethoxycoumarin ≥97% (HPLC)
- 包装単位10mg
- 価格¥116000
- 更新しました2023-06-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号UC455
- 製品説明 ≥97% (HPLC)
- 英語製品説明3-Cyano-7-ethoxycoumarin ≥97% (HPLC)
- 包装単位5mg
- 価格¥34700
- 更新しました2023-06-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式会社(wako) | W01TOC4815 | 3-Cyano-7-ethoxycoumarin |
10mg | ¥25000 | 2021-03-23 | 購入 |
富士フイルム和光純薬株式会社(wako) | W01TOC4815 | 3-Cyano-7-ethoxycoumarin |
50mg | ¥94000 | 2021-03-23 | 購入 |
Sigma-Aldrich Japan | UC455 | ≥97% (HPLC) 3-Cyano-7-ethoxycoumarin ≥97% (HPLC) |
10mg | ¥116000 | 2023-06-01 | 購入 |
Sigma-Aldrich Japan | UC455 | ≥97% (HPLC) 3-Cyano-7-ethoxycoumarin ≥97% (HPLC) |
5mg | ¥34700 | 2023-06-01 | 購入 |
プロパティ
融点 :210-212°C
沸点 :396.8±42.0 °C(Predicted)
比重(密度) :1.29±0.1 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :DMSO: soluble
外見 :Solid
色 :yellow to orange
極大吸収波長 (λmax) :356 nm (Buffer pH7); 355 nm(MeOH)
生物学的応用 :As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
沸点 :396.8±42.0 °C(Predicted)
比重(密度) :1.29±0.1 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :DMSO: soluble
外見 :Solid
色 :yellow to orange
極大吸収波長 (λmax) :356 nm (Buffer pH7); 355 nm(MeOH)
生物学的応用 :As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
安全情報
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注意喚起語: | Warning | ||||||||||||||||||||||||||||
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注意書き: |
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説明
This reagent is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. The product of the reaction is the fluorescent compound 3-cyano-7-hydroxycoumarin (Product No. C 2737). This property has been utilized to determine the activity of CYP1A by measuring the rate of dealkylation of 3-Cyano-7-ethoxycoumarin to this fluorescent product. Fluorescence of 3-cyano-7-hydroxycoumarin occurs at neutral pH with excitation and emission at 408 and 450 nm, respectively. Fluorescent reaction product detection is at least 50-fold more sensitive than that of the product of alkyl resorufin oxidation because of greater rate of turnover of 3-Cyano-7-ethoxycoumarin. The ability to continuously monitor the enzyme reaction at pH 7 is derived from the lower pKa of the 3-cyano-7- hydroxycoumarin product compared to that for 7-ethoxycoumarin. 3-Cyano-7-ethoxycoumarin is a suitable substrate for three of the five principal cytochrome P450 drug metabolizing enzymes, CYP1A1, CYP1A2, CYP2C9, and CYP2C19. It has been used to measure cytochrome P450 mixed-function monooxygenases in rat hepatic microsomal preparations as well as in isolated rat hepatocytes. It was part of a study to examine the expression of CYP2B6 in human liver microsomes, and has been used to characterize Clara and type II cells from rat lung.関連商品価格
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¥25000-116000