ARP100
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1物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 5mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC2621
- 製品説明
- 英語製品説明ARP 100
- 包装単位5mg
- 価格￥52000
- 更新しました2023-06-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TOC2621 | ARP 100 |
5mg | ￥52000 | 2023-06-01 | 購入 |
プロパティ
貯蔵温度 :Desiccate at +4°C
溶解性 :Soluble at 100mM in DMSO
外見 :Solid
色 :Off-white to light yellow
溶解性 :Soluble at 100mM in DMSO
外見 :Solid
色 :Off-white to light yellow
安全情報
| 絵表示(GHS): |
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| 注意喚起語: | Warning | ||||||||||||||||||||||||||||
| 危険有害性情報: |
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説明
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. During cancer progression both MMP-2 and MMP-9 play a role in metastatic tumor dispersion and angiogenesis. ARP 100 is a biphenylsulfonamide that acts as a selective inhibitor of MMP-2 demonstrating an IC50 value of 12 nM. Due to its specific zinc binding domain configuration, the inhibitory activity of ARP 100 is significantly less potent towards MMP-1, MMP-3, MMP-7, and MMP-9 (IC50 values are 50, 4.5, 50, and 2 μM, respectively). At 50 nM, ARP 100 suppresses the invasive behavior of HT1080 tumor cells grown on matrigel.関連製品価格