DIFOPEIN
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- 富士フイルム和光純薬株式会社(wako)
- 100μg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC2145
- 製品説明
- 英語製品説明Difopein
- 包装単位100μg
- 価格¥73000
- 更新しました2018-12-26
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式会社(wako) | W01TOC2145 | Difopein |
100μg | ¥73000 | 2018-12-26 | 購入 |
プロパティ
水溶解度 :Soluble to 5 mg/ml in Water
安全情報
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説明
Difopein is an inhibitor of 14-3-3 protein.
14-3-3 protein has been involved in a wide range of biologic processes such as signal transduction, vesicular transport, cell cycle control, DNA replication, DNA repair and apoptosis. 14-3-3 protein has been associated with tumor genesis. 14-3-3 protein correlates with reduced tumor cell apoptosis and abbreviated patient survival. Up-regulation of 14-3-3 protein provides a survival advantage to tumor cells. Inhibition of 14-3-3 protein might trigger apoptosis, inhibit growth of established tumors, suppress de novo tumor formation, and promise a novel therapeutic approach for glioma treatment [1].
In human glioma U251 and U87 cells, difopein resulted in apoptosis characteristics, such as nuclear fragmentation, DNA laddering fragment and appearance of membrane-enclosed apoptotic bodies. Difopein induced apoptosis in a time-dependent manner [1]. Difopein induced glioma cell apoptosis through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3. In vivo, difopein effectively hindered proliferation and triggered apoptosis of tumor cells implanted into nude mice [1].
関連製品価格
関連商品価格
- H-LEU-GLU-OH
¥70000-208000 - DIFOPEIN
¥73000-73000