ガナキソロン

プロパティ

安全情報

説明

Ganaxolone is a synthetic neurosteroid which functions as a stereoselective modulator of GABA_A receptors. Studies indicate that ganaxolone enhances GABA-evoked chloride currents in Xenopus oocytes. It is known that the compound modulates GABA_A receptors by inhibiting GABA_A receptor-chloride channel ligand binding and enhancing ligand binding at the benzodiazepine site. Alternatively, ganaxolone increases serotonergic neuron firing in rats after 3 to 7 days. Studies conducted on animal seizure models demonstrate that ganaxolone displays anticonvulsant effects. Furthermore, ganaxolone suppresses seizures in mice induced by maximal electroshock (ED₅₀ of 29.7 mg/kg i.p.).