| | 952021-60-2 Basic information More.. |
| Product Name: | PF 477736 | | Synonyms: | PF 477736;PF-00477736;PF-736;(αR)-α-AMino-N-[5,6-dihydro-2-(1-Methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetaMide;PF 477736(PF-0044736);(2R)-2-aMino-2-cyclohexyl-N-[2-(1-Methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7,11-pentaen-6-yl]acetaMide;PF0044736;PF-0044736 | | CAS: | 952021-60-2 | | MF: | C22H25N7O2 | | MW: | 419.49 | | EINECS: | | | Mol File: | 952021-60-2.mol |  |
Use
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.[Cayman Chemical]
- PF 477736
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- US $0.00-0.00 / G
- 2022-05-30
- CAS:952021-60-2
- Min. Order: 1G
- Purity: 98%+
- Supply Ability: 1G,10G ,100G 1KG
- PF 477736
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- US $7.00 / KG
- 2019-07-06
- CAS: 952021-60-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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952021-60-2
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