Tobramycin sulfate

Use

Introduced in 1976, tobramycin sulfate (Nebcin) is the mostactive of the chemically related aminoglycosides called nebramycinsobtained from a strain of Streptomyces tenebrarius Five members of the nebramycin complex have beenidentified chemically.Factors 4 and 4＇ are 6＂-O-carbamoylkanamycin B andkanamycin B, respectively; factors 5＇ and 6 are 6＂-O-carbamoyltobramycinand tobramycin; and factor 2 isapramycin, a tetracyclic aminoglycoside with an unusual bicycliccentral ring structure. Kanamycin B and tobramycinprobably do not occur in fermentation broths per se but areformed by hydrolysis of the 6-O＂-carbamoyl derivatives inthe isolation procedure.The most important property of tobramycin is its activityagainst most strains of P. aeruginosa, exceeding that of gentamicinby twofold to fourfold. Some gentamicin-resistantstrains of this troublesome organism are sensitive to tobramycin,but others are resistant to both antibiotics. OtherGram-negative bacilli and staphylococci are generally moresensitive to gentamicin. Tobramycin more closely resembleskanamycin B in structure (it is 3＇-deoxykanamycin B).

Tobramycin sulfate manufacturers

• Tobramycin Sulfate
• 
• US $54.00-33.00 / mg
• 2024-10-28
• CAS:49842-07-1
• Min. Order:
• Purity:
• Supply Ability: 10g

• Tobramycin sulfate
• 
• US $1.00 / kg
• 2023-04-12
• CAS:49842-07-1
• Min. Order: 1kg
• Purity: 99.74% HPLC
• Supply Ability: 5000tons/year

• Tobramycin sulfate
• 
• US $1.00 / KG
• 2020-01-03
• CAS:49842-07-1
• Min. Order: 1KG
• Purity: 99%
• Supply Ability: 10000KGS