| 866022-28-8 Basic information More.. |
Product Name: | Bischloroanthrabenzoxocinone | Synonyms: | Bischloroanthrabenzoxocinone;BABX;6,16-Epoxy-14H-anthra[2,3-d][1]benzoxocin-14-one, 10,12-dichloro-6,7,9,16-tetrahydro-11,13,15-trihydroxy-3-methoxy-1,6,9,9-tetramethyl-, (6R,16R)- | CAS: | 866022-28-8 | MF: | C28H24Cl2O7 | MW: | 543.392 | EINECS: | | Mol File: | 866022-28-8.mol | |
Use
Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 μg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. FASII is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding to Liver X receptors (LXR). These receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.
|
866022-28-8
Recommend Suppliers |
|