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Product Name:AGI6780
Synonyms:AGI6780;AGI-6780, >=98%;N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780;CS-1019
CAS:1432660-47-3
MF:C21H18F3N3O3S2
MW:481.51
EINECS:
Mol File:1432660-47-3.mol
1432660-47-3

Use

AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples.

AGI6780 manufacturers

  • AGI-6780
  • US $31.00-122.00 / mg
  • 2024-11-08
  • CAS:1432660-47-3
  • Min. Order:
  • Purity: 98.19%
  • Supply Ability: 10g
  • AGI6780
  • US $0.00-0.00 / KG
  • 2024-11-05
  • CAS:1432660-47-3
  • Min. Order: 5g
  • Purity: 99% HPLC
  • Supply Ability: 2000tons
  • AGI6780
  • US $1.00 / KG
  • 2019-07-06
  • CAS:1432660-47-3
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
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