| | 38966-21-1 Basic information More.. |
| Product Name: | APHIDICOLIN | | Synonyms: | (3-ALPHA,4-ALPHA,5-ALPHA,17-ALPHA)-3,17-DIHYDROXY-4-METHYL-9,15-CYCLO-C,18-DINOR-14,15-SECOANDROSTANE-4,17-DIMETHANOL;(+)-APHIDICOLIN;APHIDICOLIN;(+)-APHIDICOLIN, NIGROSPORA ORYZAE;,11a-beta,11b-beta))-;9-dimethanol,tetradecahydro-3,9-11a-methano-11ah-cyclohepta(a)naphthalene-4;dihydroxy-4,11b-dimethyl-,(3r-(3-alpha,4-alpha,4a-alpha,6a-beta,8-beta,9-beta;ici69653 | | CAS: | 38966-21-1 | | MF: | C20H34O4 | | MW: | 338.48 | | EINECS: | 609-602-3 | | Mol File: | 38966-21-1.mol |  |
Use
Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
- APHIDICOLIN
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- US $1.00 / g
- 2019-12-26
- CAS:38966-21-1
- Min. Order: 1g
- Purity: ≥98%
- Supply Ability: g/kg/Ton
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38966-21-1
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