| | 152044-53-6 Basic information More.. |
| Product Name: | Epothilone A | | Synonyms: | 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-;Epothilone-S;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;Epothile;4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetraMethyl-3- [(1E)-1-Methy;Ixabepilone Impurity 5 (Epothilone A);(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone A | | CAS: | 152044-53-6 | | MF: | C26H39NO6S | | MW: | 493.66 | | EINECS: | | | Mol File: | 152044-53-6.mol |  |
Use
Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A has been investigated in clinical trials as an antitumour agent.The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.
- Epothilone A
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- US $10.00 / g
- 2021-11-25
- CAS:152044-53-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5ton/Month
- Epothilone A
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- US $0.00-0.00 / Kg
- 2020-05-03
- CAS:152044-53-6
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 800 ton
- Epothilone A
-
- US $1.00 / KG
- 2019-07-10
- CAS:152044-53-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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152044-53-6
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