| | 835876-32-9 Basic information More.. |
| Product Name: | PlatensiMycin | | Synonyms: | PlatensiMycin;Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem;Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-;laminomycin | | CAS: | 835876-32-9 | | MF: | C24H27NO7 | | MW: | 441.474 | | EINECS: | | | Mol File: | 835876-32-9.mol |  |
Use
Platensimycin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by a target-based, whole-cell screening strategy using an antisense differential sensitivity assay, based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase (FabF) of the fatty acid synthesis pathway.
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835876-32-9
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