6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
| | 545380-34-5 Basic information More.. |
| Product Name: | 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE | | Synonyms: | QNZ;EVP 4593;EVP4593;EVP-4593;4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]-;4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine;N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediaMine;QNZ (EVP4593) | | CAS: | 545380-34-5 | | MF: | C22H20N4O | | MW: | 356.42 | | EINECS: | | | Mol File: | 545380-34-5.mol |  |
Use
QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
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545380-34-5
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