| | 154323-57-6 Basic information More.. |
| Product Name: | Almotriptan | | Synonyms: | LAS-31416-d6;ALMOTRIPTAN(SUBJECTTOPATENETFREE);Almotriptan;N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]-ethanamine;dimethyl-[2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethyl]amine;AlMotriptan API;N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-Indole-3-ethanamine;ALMOTRIPTAN-D6 | | CAS: | 154323-57-6 | | MF: | C17H25N3O2S | | MW: | 335.46 | | EINECS: | 1312995-182-4 | | Mol File: | 154323-57-6.mol |  |
Use
Almotriptan was first marketed in Spain as a new medicine against acute attacks of migraine. It is the fifth agent belonging to the “triptan” class to be launched after sumatriptan, naratriptan, zolmitriptan and rizatriptan. Almotriptan acts as a dual 5-HT1D/1B agonist with a 35 to 51-fold selectivity versus 5-HT1A and 5-HT7 receptors respectively as well as having insignificant affinity for the most relevant nonserotonergic receptors (K1＞1μM). Its agonistic effect on 5-HT,n receptors of trigeminal sensory neurons turns off neurogenic inflammation by inhibiting the release of neuropeptides such as calcitonin gene-related peptide, neurokinin A and substance P.
- Almotriptan
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- US $7.00 / kg
- 2019-07-06
- CAS: 154323-57-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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154323-57-6
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