| | 877617-45-3 Basic information More.. |
| Product Name: | F-AMidine | | Synonyms: | F-AMidine;N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide;F amidine,Famidine;Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]- | | CAS: | 877617-45-3 | | MF: | C14H19FN4O2 | | MW: | 294.32 | | EINECS: | | | Mol File: | 877617-45-3.mol |  |
Use
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).
|
|
877617-45-3
Recommend Suppliers |
|