| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:F-AMidine
CAS:877617-45-3
Package:2.5Mg,25Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:F-AMidine;N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide
CAS:877617-45-3
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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- F-amidine
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- $1520.00 / 25mg
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2024-10-28
- CAS:877617-45-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | F-AMidine Basic information |
| | F-AMidine Chemical Properties |
| density | 1.27±0.1 g/cm3(Predicted) | | pka | 13.26±0.46(Predicted) |
| | F-AMidine Usage And Synthesis |
| Uses | An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively). | | Definition | ChEBI: F-Amidine is a N-acylglycine. |
| | F-AMidine Preparation Products And Raw materials |
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