23313-68-0 Basic information More..
Product Name:Verapamil hydrochloride
Synonyms:CALAN;IPROVERATRIL;(+/-)-5-[N-(3,4-DIMETHOXYPHENYLETHYL)-METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE;5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE;alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride;ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)BENZENEACETONITRILE HYDROCHLORIDE;5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE;(+/-)-VERAPAMIL HYDROCHLORIDE
CAS:23313-68-0
MF:C27H39ClN2O4
MW:491.06
EINECS:245-579-2
Mol File:23313-68-0.mol
23313-68-0

Use

Verapamil hydrochloride (VRP) is a phenylalkylamine calcium ion influx inhibitor (calcium antagonist). Verapamil hydrochloride exerts its pharmacologic effects by modulating the influx of ionic through the slow channels of vascular smooth muscle and cardiac cell membranes. It is widely used for the treatment of hypertension, angina pectoris, supraventricular tachycardia, myocardial infraction, and vascular headaches. Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines The plasma half-life of verapamil hydrochloride is 2–7 hours, which necessitates multiple dosing. After oral administration of VRP to humans, the drug is rapidly absorbed and widely distributed. It is approximately 90% absorbed from the gastrointestinal tract but is subject to considerable first pass metabolism and its bioavailability is around 20–30%. The low bioavailability is owing to the rapid biotransformation in the liver with a biological half-life of 4.0±1.5 hours.

Verapamil hydrochloride manufacturers

  • Verapamil hydrochloride
  • US $0.00 / KG
  • 2024-11-04
  • CAS:23313-68-0
  • Min. Order: 1KG
  • Purity: 99%,USP
  • Supply Ability: 500kg/month
  • Verapamil hydrochloride
  • US $15.00-10.00 / KG
  • 2021-07-10
  • CAS:23313-68-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Information Error Report
Your Email:
23313-68-0 Recommend Suppliers
Recommend You Select Member Companies...
Company Name: Shaanxi TNJONE Pharmaceutical Co., Ltd      Recommend     Complaint
Tel:
FAX:
Email: sarah@tnjone.com
Nationality: China
Products Intro: Product Name:Verapamil Hydrochloride
CAS:23313-68-0
Purity:99% Package:1kg
CB Index: 58
WebSite: tnjone.com
Related Information: Sales Network   Catalog(1143)   User Evaluation
Company Name: Longyan Tianhua Biological Technology Co., Ltd      Recommend     Complaint
Tel: 0086 18039857276
FAX:
Email:
Nationality: CHINA
Products Intro: Product Name:Verapamil hydrochloride
CAS:23313-68-0
Purity:99 Package:1KG;100USD
CB Index: 58
WebSite: tianhuaapi.en.alibaba.com
Related Information: Sales Network   Catalog(2783)   User Evaluation
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.      Recommend     Complaint
Tel: +86-0551-65418671
FAX: 0551-65418697
Email: sales@tnjchem.com
Nationality: China
Products Intro: Product Name:Verapamil hydrochloride
CAS:23313-68-0
CB Index: 58
WebSite: www.tnjchem.com
Related Information: Sales Network   Catalog(34553)   User Evaluation
Company Name: Shaanxi Dideu Medichem Co. Ltd      Recommend     Complaint
Tel: +86-029-89586680
FAX: +86-29-88380327
Email: 1026@dideu.com
Nationality: China
Products Intro: Product Name:Verapamil hydrochloride USP/EP/BP
CAS:23313-68-0
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
CB Index: 58
WebSite: www.dideu.com
Related Information: Sales Network   Catalog(7724)   User Evaluation
Company Name: Wuhan Fortuna Chemical Co., Ltd      Recommend     Complaint
Tel: +86-027-59207850
FAX: 86-27-59524646
Email: info@fortunachem.com
Nationality: China
Products Intro: Product Name:Verapamil hydrochloride
CAS:23313-68-0
Purity:99%,USP Package:1KG;0USD
CB Index: 58
WebSite: www.fortunachem.com/
Related Information: Sales Network   Catalog(5986)   User Evaluation
Company Name: Baoji Guokang Bio-Technology Co., Ltd.      Recommend     Complaint
Tel: 0917-3909592
FAX: 09173909592
Email: gksales1@gk-bio.com
Nationality: China
Products Intro: Product Name:Verapamil hydrochloride
CAS:23313-68-0
Purity:0.98 Package:1KG
CB Index: 58
WebSite: http://www.gk-bio.com
Related Information: Sales Network   Catalog(9315)   User Evaluation
Company Name: Wuhan Golt Biotech Co., Ltd.      Recommend     Complaint
Tel:
FAX:
Email: maria@goltbiotech.com
Nationality: China
Products Intro: Product Name:Verapamil Hcl
CAS:23313-68-0
CB Index: 58
WebSite: www.goltbiotech.com
Related Information: Sales Network   Catalog(970)   User Evaluation
Company Name: Amadis Chemical Company Limited      Recommend     Complaint
Tel: 571-89925085
FAX: 0086-571-89925065
Email: sales@amadischem.com
Nationality: China
Products Intro: Product Name:2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochloride
CAS:23313-68-0
Purity:0.97 Package:mgs,gs,kgs Remarks:A816666
CB Index: 58
WebSite: http://www.amadischem.com
Related Information: Sales Network   Catalog(131957)   User Evaluation(2)
1 2 3 4 5 6 7 8 9 10 11
Tag: 23313-68-0