- brefeldin
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- $0.00 / 1Kg
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2024-09-23
- CAS:20350-15-6
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- Brefeldin A
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- $0.00 / 1KG
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2023-09-06
- CAS:20350-15-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
- Brefeldin A
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- $14.00 / 1g
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2021-11-25
- CAS:20350-15-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5ton/Month
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| | Brefeldin Basic information |
| Product Name: | Brefeldin | | Synonyms: | NSC 107456;(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-Methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one;Ascotoxin, Cyanein, DecuMbin;Brefeldin A, FroM EupenicilliuM brefeldianuM;NECTROLIDE;SYNERGISIDIN;4h-cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-de;cahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl- | | CAS: | 20350-15-6 | | MF: | C16H24O4 | | MW: | 280.36 | | EINECS: | 606-528-3 | | Product Categories: | antibiotic;Signalling;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 20350-15-6.mol |  |
| | Brefeldin Chemical Properties |
| Melting point | 200-205 °C | | Boiling point | 492.7±45.0 °C(Predicted) | | alpha | 93 º (C=2 IN MEOH) | | density | 1.108±0.06 g/cm3(Predicted) | | vapor pressure | 0.56 hPa ( 20 °C) | | Fp | 87 °C | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | methanol: 10 mg/mL, clear, colorless to faintly yellow | | pka | 12.92±0.60(Predicted) | | form | Crystalline Powder | | color | White to almost white | | Water Solubility | Soluble in dimethylsulfoxide, dichloromethane and ethanol. Slightly soluble in water. | | Merck | 13,1355 | | BRN | 25191 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | InChIKey | QSECOIOBNZLGOD-OBCVZTHZSA-N | | CAS DataBase Reference | 20350-15-6 |
| Hazard Codes | Xn,T | | Risk Statements | 22-25-36/37/38-20/21/22 | | Safety Statements | 24/25-45-36-26 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | GY8410000 | | Autoignition Temperature | 301 °C | | HS Code | 29411090 | | Toxicity | LD50 i.p. in mice: >200 mg/kg (Haerri) |
| | Brefeldin Usage And Synthesis |
| Description | Brefeldin is a fungal metabolite demonstrated to reversibly interfere with anterograde transport from the endoplasmic reticulum to the Golgi apparatus.
| | Chemical Properties | Since brefeldin is combustible, contamination with oxidizing agents should be avoided to prevent the risk of fire. Direct contact should be avoided as well.
| | Physical properties |
Brefeldin is found naturally as a white to off-white crystalline solid. It forms a clear colorless solution when dissolved. It is soluble in methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL) without the aid of heating.It is poorly soluble in water (slightly miscible).
| | Uses |
While initially isolated as an antibiotic, and does have a wide range of antibiotic activity, brefeldin is primarily used as a biological research tool for studying protein transport. Treatment leads to a rapid accumulation of proteins within the ER and collapse of the Golgi stacks.
| | storage | Brefeldin is recommended that it be stored desiccate at -20°C away from direct sunlight.
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| | Brefeldin Preparation Products And Raw materials |
| Raw materials | 1-Hexanol, 5-(4-methoxyphenoxy)-, (5S)--->4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-6-methyl-1,13-bis[(4-nitrobenzoyl)oxy]-, (1R,2E,6S,10E,11aS,13S,14aR)--->4H-Cyclopent[f]oxacyclotridecin-4-one, 1,13-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,6,7,8,9,11a,12,13,14,14a-decahydro-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)- |
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