| Company Name: |
Tangyuan Life Science (Shanghai) Co., Ltd
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| Tel: |
400-618-1121 18616561988 |
| Email: |
sales@townyuan.com |
| Products Intro: |
Cas:4039-32-1
ProductName:Lithium bis(trimethylsilyl)amide, LiHMDS
Purity: 98% | Package: 1L;5L;25L
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| Company Name: |
|
| Tel: |
|
| Email: |
jsk.chemicals@gmail.com |
| Products Intro: |
Cas:4039-32-1
ProductName:Lithium bis(trimethylsilyl)amide, 20%
in THF
Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
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| Company Name: |
|
| Tel: |
|
| Email: |
sales4@oceanicpharmachem.com |
| Products Intro: |
Cas:4039-32-1
ProductName:Lithium HMDS 1.4M In THF /1.0M In Toluene / 1.4M In
Hexanes / 1.4M In MTBE / 95%
Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
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| | Lihmds 1m In Thf Basic information |
| | Lihmds 1m In Thf Chemical Properties |
| Melting point | 73°C | | Boiling point | 55-56 °C | | density | 0.860 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.425(lit.) | | Fp | 48 °F | | storage temp. | Store below +30°C. | | solubility | hydrolysis | | form | Powder | | color | White | | Specific Gravity | 0.716 | | Water Solubility | hydrolysis | | Sensitive | Air & Moisture Sensitive | | Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents | | BRN | 3567910 | | Exposure limits | ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) | | InChIKey | YNESATAKKCNGOF-UHFFFAOYSA-N | | CAS DataBase Reference | 4039-32-1(CAS DataBase Reference) | | EPA Substance Registry System | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (4039-32-1) |
| | Lihmds 1m In Thf Usage And Synthesis |
| Chemical Properties | light yellow to yellow crystalline powder | | Physical properties | distillable low-melting solid; mp 70–72 °C, bp
115 °C/1mmHg. LHMDS is a cyclic trimer in the solid state,3
whereas in benzene solution it exists in a monomer–dimer
equilibrium. LHMDS exists as a tetramer-dimer mixture in
hydrocarbons and as a dimer-monomer mixture in THF and
ether. Treatment of LHMDS with trialkylamines increases the
monomer concentration, whereas the use of diamines affords
exclusively the corresponding chelated monomer. LHMDS
is less soluble, less basic, more stable, and much less sensitive
to air compared to lithium diisopropylamide. pKa 29.5 (THF,
27 °C). | | Uses | Lithium Hexamethyldisilazide is widely used as strong nonnucleophilic base | | Uses | Lithium bis(trimethylsilyl)amide is a base used in preparation of dienes and enolates. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines. Lithium bis(trimethylsilyl)amide is also used in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles. | | Uses | Lithium bis(trimethylsilyl)amide is used as nonnucleophilic base to generate kinetic ketone and ester enolates. It is considerably more selective than LDA and undesired reductions (e.g., of nonenolizable ketones observed in the case of LDA) can be avoided by using LHMDS. | | Preparation | It is conveniently prepared by the reaction of
hexamethyldisilazane with n-butyllithium in hexane. For most
uses the hexane is then evaporated and replaced with THF. | | General Description | This product, 0.5 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention. | | Flammability and Explosibility | Highly flammable |
| | Lihmds 1m In Thf Preparation Products And Raw materials |
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