| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
|
| Tel: |
0512-65118909 15162312715 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Cas:1062368-24-4
ProductName:LDN193189
Purity: 98%+ | Package: 1g;10g;100g
|
| Company Name: |
SHANGHAI ZZBIO CO., LTD.
|
| Tel: |
15102117276 19921389125 |
| Email: |
tech@zzbioco.com |
| Products Intro: |
Cas:1062368-24-4
ProductName:LDN193189
Purity: 0.95 | Package: 50mg;
|
- LDN193189
-
- $41.00 / 2mg
-
2024-10-29
- CAS:1062368-24-4
- Min. Order:
- Purity: 99.86%
- Supply Ability: 10g
|
| | Ldn193189 Basic information |
| Product Name: | Ldn193189 | | Synonyms: | LDN193189
LDN193189 HCl;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline;LDN193189(DM3189);4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;DM 3189;DM-3189;6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyriMidine LDN 193189(DM3189);4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[ | | CAS: | 1062368-24-4 | | MF: | C25H22N6 | | MW: | 406.48 | | EINECS: | | | Product Categories: | Smad;TGF-beta;Inhibitors;TGF-beta/Smad | | Mol File: | 1062368-24-4.mol |  |
| | Ldn193189 Chemical Properties |
| density | 1.33 | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | H2O: soluble5mg/mL, clear (warmed) | | form | powder | | pka | 8.79±0.10(Predicted) | | color | yellow to orange | | InChIKey | XHBVYDAKJHETMP-UHFFFAOYSA-N |
| WGK Germany | 3 | | HS Code | 29339900 |
| | Ldn193189 Usage And Synthesis |
| Biological Activity | LDN-193189 is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For animal testing, the water-soluble S7507 LDN-193189 2HCl is recommended. |
| | Ldn193189 Preparation Products And Raw materials |
|