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Human Stem Cell Factor

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Human Stem Cell Factor manufacturers
Human Stem Cell Factor Basic information
Product Name:Human Stem Cell Factor
Synonyms:RECOMBINANT HUMAN SCF;REC STEM CELL FACTOR (HUMAN);REC SCF (HUMAN);SCF, HUMAN;STEM CELL FACTOR, HUMAN;STEM CELL FACTOR, HUMAN, RECOMBINANT;STEM CELL FACTOR, HUMAN, RECOMBINANT, E COLI;MAST CELL GROWTH FACTOR HUMAN
CAS:133352-98-4
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Human Stem Cell Factor Structure
Human Stem Cell Factor Chemical Properties
storage temp. −20°C
form powder
Safety Information
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26
WGK Germany 3
HS Code 2937190000
MSDS Information
ProviderLanguage
SigmaAldrich English
Human Stem Cell Factor Usage And Synthesis
General DescriptionThe KITLG (KIT ligand) gene is mapped to human chromosome 12q21.32.
Biochem/physiol ActionsStem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors.
Human Stem Cell Factor Preparation Products And Raw materials
Tag:Human Stem Cell Factor(133352-98-4) Related Product Information
Benzyl isocyanide Ethyl isocyanoacetate PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) TERT-BUTYL ISOCYANIDE Ferric acetylacetonate Cupric acetylacetonate Aluminum acetylacetonate METHYL ISOCYANOACETATE SALCOMINE N-BUTYLISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) COBALT(II) ACETYLACETONATE Human Scf Recombinant Human Scf