类叶升麻苷
| 中文名称 | 类叶升麻苷 |
|---|---|
| 中文同义词 | 毛蕊花糖苷 、类叶升麻苷;毛蕊花苷;毛蕊花糖苷(麦角甾苷,阿克苷,类叶升麻苷);类叶升麻苷/毛蕊花糖苷;类叶升麻苷,毛蕊花糖苷(标准品);ACTEOSIDE 类叶升麻苷/毛蕊花糖苷;麦角甾苷, 来源于肉苁蓉;麦角甾苷(毛蕊花糖苷) |
| 英文名称 | Verbascoside |
| 英文同义词 | glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos;ACTEOSIDE :B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-A-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-,;Extract from Verbena minutiflora (B864379);[(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate;VERBASCOSIDE WITH HPLC;2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate];3,4-Dihydroxyphenethyl alcohol acteoside;Verbacoside |
| CAS号 | 61276-17-3 |
| 分子式 | C29H36O15 |
| 分子量 | 624.59 |
| EINECS号 | |
| 相关类别 | 天然产物;中药对照品;标准品;对照品,标准品;分析标准品;植物提取物;对照品;植提标准品;食品和饮料标准品;分析试剂标准品;标准品-对照品;细胞生物学试剂;标准品-中药标准品;标准品，对照品;标准品 -中药标准品;Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;其它酚类;分析试剂-对照品;原料;植物提取物单体 |
| Mol文件 | 61276-17-3.mol |
| 结构式 |  |
类叶升麻苷 性质
| 熔点 | 232℃ |
|---|---|
| 沸点 | 908.8±65.0 °C(Predicted) |
| 密度 | 1.60±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO（微溶）、乙酸乙酯（微溶）、甲醇（微溶） |
| 酸度系数(pKa) | 9.31±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
| 稳定性 | 吸湿性 |
| InChIKey | FBSKJMQYURKNSU-ZLSOWSIRSA-N |
| LogP | 0.077 (est) |
| CAS 数据库 | 61276-17-3(CAS DataBase Reference) |
|
PKC 25 μM (IC 50 ) |
Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC 50 of 25 µM. Verbascoside shows K i s of 22 and 28 µM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC 50 of 13 µM. Verbascoside (5, 10 µM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells.
Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3.
药理药效:具有调节免疫、抗氧化、增强体力、抗疲劳、等药理作用。
安全信息
| 安全说明 | 24/25 |
|---|---|
| WGK Germany | 2 |
| RTECS号 | LZ5786000 |
| 海关编码 | 29389090 |
| 毒性 | LD50 oral in rat: > 5gm/kg |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/11 | XW6127617301 | 毛蕊花糖苷 | 61276-17-3 | 25MG | 495元 |
| 2024/11/08 | HY-N0021 | Verbascoside | 5 mg | 400元 |