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Deoxycholate
Deoxycholic acid (conjugate base deoxycholate), also known as cholanoic acid, Kybella, Celluform Plus and 3α, 12α-dihydroxy-5β-cholan-24-oic acid, is a secondary bile acid produced from cholic acid by bacterial action in the colon. Deoxycholic acid is soluble in alcohol and acetic acid. When pure, it comes in a white to off-white crystalline powder form. It is usually conjugated with glycine or taurine and acts as a detergent in the emulsification of fats for intestinal absorption. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic appearance and reduce facial fullness or convexity.
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| | Deoxycholate Chemical Properties |
| Melting point | 171-174 °C(lit.) | | Boiling point | 437.26°C (rough estimate) | | alpha | 55 º (c=1, EtOH) | | density | 0.9985 (rough estimate) | | vapor pressure | 0.004Pa at 20℃ | | refractive index | 1.4460 (estimate) | | Fp | 9℃ | | storage temp. | room temp | | solubility | 0.24 g/L (15°C) | | pka | 5.15(at 20℃) | | form | Solid | | color | White to Off-White | | optical activity | [α]20/D +54±1°, c = 1% in ethanol | | Water Solubility | 0.24 g/L (15 ºC) | | Merck | 14,2899 | | BRN | 3219882 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | LogP | 5.34 at 22℃ and pH5.7 | | Surface tension | 54mN/m at 51.3mg/L and 20℃ | | CAS DataBase Reference | 83-44-3(CAS DataBase Reference) | | EPA Substance Registry System | Cholan-24-oic acid, 3,12-dihydroxy-, (3.alpha.,5.beta.,12.alpha.)- (83-44-3) |
| | Deoxycholate Usage And Synthesis |
| Uses | Deoxycholate is used to treat and improve bulging or fullness of submental fat (double chin) in adults with moderate to severe submental fat. | | Biological Activity | Deoxycholate is a free bile acid present in bile. It has strong surface activity and can destroy and dissolve cell membranes, reducing the dissolution of subcutaneous fat in a small area.
| | Mechanism of action | As a bile acid, deoxycholate emulsifies fat in the gut. Synthetically derived deoxycholic acid, when injected, stimulates a targeted breakdown of adipose cells by disrupting the cell membrane and causing adipocytolysis. This results in an inflammatory reaction and clearing of the adipose tissue remnants by macrophages. Deoxycholate's actions are reduced by albumin and tissue-associated proteins, therefore its effect is limited to protein-poor subcutaneous fat tissue. Protein-rich tissues like muscle and skin are unaffected by deoxycholate, contributing to its safety.
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| | Deoxycholate Preparation Products And Raw materials |
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Tag:Deoxycholate(83-44-3)
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