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Methylphenidate Hcl

Methylphenidate Hcl Basic information
Product Name:Methylphenidate Hcl
Synonyms:METHYLPHENIDATE HYDROCHLORIDE;RITALIN HYDROCHLORIDE;2-piperidineaceticacid,alpha-phenyl-,methylester,hydrochloride;meridilhydrochloride;2-Piperidineaceticacid, a-phenyl-, Methyl ester,hydrochloride (1:1);Methylphenidate hydrochloride solution;Ritalin (Methylphenidate Hcl);methylalpha-phenyl-2-piperidineacetatehydrochloride
CAS:298-59-9
MF:C14H20ClNO2
MW:269.77
EINECS:206-065-3
Product Categories:Heterocyclic Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;ASACOL;298-59-9
Mol File:298-59-9.mol
Methylphenidate Hcl Structure
Methylphenidate Hcl Chemical Properties
Melting point 196-198?C
Fp 9℃
storage temp. Store at RT
solubility Freely soluble in water, soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form Powder
pka8.9(at 25℃)
Water Solubility Soluble to 50 mM in water and to 100 mM in ethanol
BCS Class2
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, alkalies, barbiturates.
InChIInChI=1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H
InChIKeyJUMYIBMBTDDLNG-UHFFFAOYSA-N
SMILESC(C(=O)OC)(C1NCCCC1)C1C=CC=CC=1.Cl
CAS DataBase Reference298-59-9(CAS DataBase Reference)
EPA Substance Registry SystemMethylphenidate hydrochloride (298-59-9)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-42-39/23/24/25-23/24/25-11
Safety Statements 22-26-36-45-36/37-16
RIDADR 3249
WGK Germany 3
RTECS TM3850000
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 orally in mice: 190 mg/kg (Greenblatt, Osterberg)
MSDS Information
ProviderLanguage
SigmaAldrich English
Methylphenidate Hcl Usage And Synthesis
Uses

Methylphenidate Hcl is a central nervous system (CNS) stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) in adults and children. It is also used to treat a certain type of sleep disorder (episodic somnolence).

Trade nameRitalin
Side effects

Possible side effects of Methylphenidate Hcl may include: nervousness, difficulty sleeping, loss of appetite, weight loss, dizziness, nausea, vomiting or headache; it may also increase blood pressure. Serious side effects include signs of blood flow problems to the fingers or toes (e.g. coldness, numbness, pain or change in skin colour), unusual cuts on the fingers or toes, fast/irregular heartbeat, mental/mood/behavioural changes (e.g. agitation, aggression, mood swings, unusual thoughts, suicidal thoughts), uncontrolled muscle movements (e.g. twitching, trembling), fainting, seizures, symptoms of stroke (e.g. weakness on one side of the body), difficulty in speaking, sudden vision loss. weakness, difficulty speaking, sudden vision changes, blurred consciousness). In rare cases, men (including young boys and adolescents) may experience pain or prolonged erections lasting 4 hours or more while using this medicine. Rare allergic reactions that may occur include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing. Contact your doctor promptly if you experience any of the above severe or uncomfortable sensations.

Methylphenidate Hcl Preparation Products And Raw materials
Raw materials2-Chloropyridine-->Sulfuric acid-->Sodium amide-->Methanol-->Hydrogen-->Hydrochloric acid-->Benzeneacetonitrile
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