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Somatropin

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Somatropin Basic information
Discovery Structure Gene, mRNA, and precursor Synthesis and release Agonists and Antagonists Receptors Biological functions Clinical implications
Product Name:Somatropin
Synonyms:Recombinant human somatotropin;Somatropin (8.63 USP Somatropin Units/vial) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED);SoMatotropin (huMan)(9CI);Growth Hormone from chicken;cb311;crecormon;SOMATOTROPIN (STH), HUMAN PITUITARY, RECOMBINANT, EXPRESSED IN ESCHERICHIA COLI;RecombinantHumanGrowthHormonePowderMateirals/Rhgh
CAS:12629-01-5
MF:C990H1529N263O299S7
MW:22124.12
EINECS:235-735-8
Product Categories:Steroid and Hormone;medical intermediate;Human growth hormone;hgh
Mol File:Mol File
Somatropin Structure
Somatropin Chemical Properties
alpha 25 -38.7° (0.1M acetic acid)
storage temp. 2-8°C
form lyophilized powder
CAS DataBase Reference12629-01-5
Safety Information
Hazard Codes B
WGK Germany 3
RTECS TO7385000
HS Code 2937110000
ToxicityLD50 oral in rat: 160iu/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
Somatropin Usage And Synthesis
DescriptionSomatropin is a drug that has been approved by the U.S. Food and Drug Administration (FDA) for various uses, though it is mainly used to treat growth disorders in children and growth hormone deficiency in adults. Somatropin is FDA-approved under the brand name Serostim to treat HIV-associated wasting or cachexia in people with HIV. Off-label use of somatropin may include treatment of HIV-associated lipodystrophy syndrome.
Indications

Somatotropin has approved indications in both the adult and pediatric populations. In the United States, recombinant human growth hormone is used in the pediatric population to treat short stature due to growth hormone deficiency (including idiopathic [of unknown cause] growth hormone deficiency), Turner syndrome, Noonan syndrome, Prader-Willi syndrome, short stature homeobox-containing gene (SHOX) deficiency, chronic renal insufficiency, idiopathic short stature and children small for gestational age.

Side effects

Common side effects of Somatropin may include:
pain, itching, or skin changes where the medicine was injected;
swelling, rapid weight gain;
muscle or joint pain;
numbness or tingling;
stomach pain, gas;
headache, back pain;
orcold or flu symptoms, stuffy nose, sneezing, sore throat, ear pain.

Somatropin Preparation Products And Raw materials
Tag:Somatropin(12629-01-5) Related Product Information
N-BUTYLISOCYANIDE Tosylmethyl isocyanide SALCOMINE TERT-BUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tris(2,4-pentanedionato)chroMiuM(III) METHYL ISOCYANOACETATE Ethyl isocyanoacetate Cupric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate Aluminum acetylacetonate PHENYLSELENOL GROWTH HORMONE, HUMAN,GROWTH HORMONE, HUMAN PITUITARY Human Growth Hormone