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| | Ursodeoxycholic Chemical Properties |
| Melting point | 203-204 °C (lit.) | | Boiling point | 437.26°C (rough estimate) | | alpha | 60 º (c=2, EtOH) | | density | 0.9985 (rough estimate) | | refractive index | 60.5 ° (C=2, EtOH) | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | ethanol: 50 mg/mL, clear | | pka | pKa 5.04±0.04(H2O
t = 25.0±0.1
I = 0.00)(Approximate) | | form | Solid. Powder. | | color | White - almost white. | | Water Solubility | practically insoluble | | Merck | 14,9889 | | BRN | 3219888 | | InChIKey | RUDATBOHQWOJDD-UZVSRGJWSA-N | | LogP | 3-3.38 at 20℃ | | CAS DataBase Reference | 128-13-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 24/25-36-26 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 2 | | RTECS | FZ2000000 | | F | 10 | | HS Code | 29181990 | | Toxicity | LD50 in mice (g/kg): 0.1 i.v. (Ardenne, Reitnauer); in rats, mice (mg/kg): 2000, 6000 s.c.; 1000, 1200 i.p., 310, 260 i.v. (Ward) |
| | Ursodeoxycholic Usage And Synthesis |
| Description | Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool. It is a medication used in the management and treatment of cholestatic liver disease. | | Uses | Ursodeoxycholic acid is a naturally occurring hydrophilic bile acid which has been demonstrated to decrease cholestasis. Ursodiol has been postulated to reduce the hydrophobic bile acids in the hepatobiliary system to lessen the potential for hepatotoxicity. It has been extensively evaluated in prophylaxis of SOS, with modest benefits. Ursodiol has also been postulated to exhibit immunomodulatory and antiapoptotic properties and may be used as an adjunctive therapy for patients with acute or chronic GVHD of the liver. |
| | Ursodeoxycholic Preparation Products And Raw materials |
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