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| | Ly3502970 Basic information |
| Product Name: | Ly3502970 | | Synonyms: | 1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcy...;GLP-1 receptor agonist 1 USP/EP/BP;LY3502970;Orforglipron;Orforglipron（LY3502970）;LY3502970 (Orforglipron);3-((1S,2S)-1-(5-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one;OWL 833 | | CAS: | 2212020-52-3 | | MF: | C48H48F2N10O5 | | MW: | 882.97 | | EINECS: | | | Product Categories: | 1 | | Mol File: | 2212020-52-3.mol |  |
| | Ly3502970 Chemical Properties |
| density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (141.57 mM) | | form | Solid | | pka | 7.33±0.20(Predicted) | | color | Off-white to light yellow | | InChIKey | USUWIEBBBWHKNI-BBGRWQLENA-N |
| | Ly3502970 Usage And Synthesis |
| Uses | Orforglipron (LY3502970) (Compound 67) is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorates the type 2 diabete. | | Mechanism of action | Ly3502970 is an incretin secreted from L cells of the small intestine when nutrients pass through the digestive tract, and glucose is transmitted via the GLP-1 receptor. Ly3502970 exhibits various actions such as dependent gastric emptying delay, and feeding suppression. |
| | Ly3502970 Preparation Products And Raw materials |
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