补骨脂二氢黄酮
中文名称 | 补骨脂二氢黄酮 |
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中文同义词 | 补骨脂甲素(补骨脂二氢黄酮);补骨脂二氢黄酮;补骨脂二氢黄酮(标准品);补骨脂二氢黄酮/补骨脂甲素;BAVACHIN 补骨脂二氢黄酮/补骨脂甲素;补骨脂二氢黄酮/补骨脂甲素标准品;BAVACHIN 补骨脂二氢黄酮/补骨脂甲素 标准品;补骨脂甲素, 分析对照品 |
英文名称 | BAVACHIN |
英文同义词 | BAVACHIN;(S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-;Bavachin from Psoralea coryfolia, >=97% (HPLC);(2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one |
CAS号 | 19879-32-4 |
分子式 | C20H20O4 |
分子量 | 324.37 |
EINECS号 | |
相关类别 | 中药对照品;标准品;对照品,标准品;有机砌块;植物提取物;对照品;植提标准品;酮;分析试剂标准品;标准品-对照品;对照品-中药对照品;黄酮;标准品 -中药标准品;分析试剂-标准品;标准品,对照品 |
Mol文件 | 19879-32-4.mol |
结构式 | ![]() |
补骨脂二氢黄酮 性质
沸点 | 558.3±50.0 °C(Predicted) |
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密度 | 1.244 |
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
溶解度 | 乙醇中≤20mg/ml;DMSO 中≤30mg/ml;二甲基甲酰胺中≤50mg/ml |
形态 | 结晶固体 |
酸度系数(pKa) | 8.27±0.40(Predicted) |
颜色 | 白色 |
CAS 数据库 | 19879-32-4 |
IC50: 320 nM (ERα), 680 nM (ERβ)
Bavachin significantly inhibits melanin synthesis and TYR activity. Bavachin (10 µM) inhibits the expression of TYR and JNK proteins, and the expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2 mRNA in A375 cells. ICI182780 and U0126 cAN significantly reverse the bavachin treatment on the protein expression levels and the mRNA expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2. Bavachin accumulates lipid in a dose dependent manner in ORO staining experiments. Bavachin significantly increases the growth of preadipoctye at 10 µM compared with the control cells in MTT assay. Bavachin also increases BrdU incorporation into newly synthesized DNA during pre-adipocyte proliferation. BrdU incorporation is enhanced by insulin and further enhanced by co-treatment with insulin and bavachin at 2 and 10 µM. Bavachin activates adipogenic factors and increases PPARγ transcriptional activity in differentiated adipocytes. Bavachin enhances insulin-stimulated glucose uptake through GLUT4 translocation via Akt and AMPK pathway. BVN significantly increases both hMAO-A and hMAO-B activities. Bavachin shows ER ligand binding activity in competitive displacement of [ 3 H] E2 from recombinant ER. The estrogenic activity of bavachin is characterized in a transient transfection system using ERα or ERβ and estrogen-responsive luciferase plasmids in CV-1 cells with an EC 50 of 320 nM and 680 nM, respectively. Bavachin increases the mRNA levels of estrogen-responsive genes such as pS2 and PR, and decreases the protein level of ERα by proteasomal pathway.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0233 | Bavachin | 1 mg | 300元 | |
2024/08/19 | HY-N0233 | 补骨脂甲素 Bavachin | 19879-32-4 | 5mg | 500元 |