Log in | Join Free | china | japan | germany
ChemicalBook > Product Catalog >API >Antipyretic analgesics >Antipyretic analgesics >Metamizole

Metamizole

Request For Quotation

Metamizole manufacturers
Metamizole Basic information
Overview Indication Pharmacological effects and Mode of action Adverse reaction Warning and precaution References
Product Name:Metamizole
Synonyms:Dipyrone,hydrate;ANALGIN:DIPYRONE:/METAMIZOLE SODIUM;DIPYRON HYDRATE VETRANAL;ANALGINE, PHARMA;DIPYRONE SODIUM SALT;ANAGRELIDEHCL;Metamizol, Methapyrone;Dipyron
CAS:5907-38-0
MF:C13H20N3NaO5S
MW:353.37
EINECS:611-790-7
Product Categories:NALLPEN;antipyretic analgesics and NSAIDS;Drug bulk;API
Mol File:5907-38-0.mol
Metamizole Structure
Metamizole Chemical Properties
Melting point 221℃
storage temp. 2-8°C
solubility H2O: soluble25mg/mL, clear
form powder
color white to beige
BRN 3865381
CAS DataBase Reference5907-38-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 63
Safety Statements 36/37
WGK Germany 3
RTECS PB1320000
MSDS Information
Metamizole Usage And Synthesis
Chemical Properties

Metamizole is a sulfonic acid and comes in calcium, sodium and magnesium salt forms. Its sodium salt monohydrate form is a white/almost crystalline powder that is unstable in the presence of light, highly soluble in water and ethanol but practically insoluble in dichloromethane.

UsesMetamizole has various effects including analgesic effect; antipyretic effect, anti-inflammatory effect and can reduce platelet aggregation. Metamizole is commonly used to treat postoperative pain, colic pain, cancer pain and migraine. In addition, it can also be used in relieving fever, and treatment of respiratory and gastroenteritic diseases.
Brand nameDiprofarn (Farmitalia, Societa Farmaceutici Italia, Italy); Novaldin (Sterling Winthrop)
Side effects

Metamizole has a potential of blood-related toxicity (blood dyscrasias), Like NSAIDs, it can trigger bronchospasm or anaphylaxis, especially in those with asthma.Serious side effects include agranulocytosis, aplastic anaemia, hypersensitivity reactions (like anaphylaxis and bronchospasm), toxic epidermal necrolysis and it may provoke acute attacks of porphyria.

Physiological effectsMetamizole has various effects including analgesic effect; antipyretic effect, anti-inflammatory effect and can reduce platelet aggregation.
Legal status

Metamizole is banned in several countries, available by prescription in others (sometimes with strong warnings, sometimes without), and available over the counter in yet others.For example, approval was withdrawn in Sweden (1974), the US (1977),and India (2013, ban lifted in 2014).

Metamizole Preparation Products And Raw materials
Tag:Metamizole(5907-38-0) Related Product Information
Sulfamic acid monosodium salt N,N-Dimethylformamide N,N-Dimethyl-1,4-phenylenediamine Dimethyl sebacate Dimethyl fumarate Triphenylmethyl Chloride Dimethyl carbonate Dacthal Chlorodimethylphenylsilane Dimethyl sulfide Dimethyl sulfoxide Tris(hydroxymethyl)aminomethane Dimethyl sulfate 4,4'-Methylenedianiline Dimethyl ether ETHANE Molasses Dibupyrone