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| | Hyoscine Butylbromide Basic information |
| | Hyoscine Butylbromide Chemical Properties |
| Melting point | 142-1440C | | alpha | D20 -20.8° (c = 3 in water) | | storage temp. | 2-8°C | | solubility | H2O: 50 mg/mL | | form | powder | | color | white | | optical activity | [α]25/D 20.8°, c = 3 in H2O(lit.) | | CAS DataBase Reference | 149-64-4(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | RTECS | YM3500000 | | Toxicity | LD50 in mice (mg/kg): 15.6 i.v.; 74 i.p.; 570 s.c.; 3000 orally (Stockhaus, Wick) |
| | Hyoscine Butylbromide Usage And Synthesis |
| Description | Hyoscine butylbromide (scopolamine butylbromide) [Buscopan/Buscapina] is an antispasmodic drug indicated for the treatment of abdominal pain associated with cramps induced by gastrointestinal (GI) spasms. It was first registered in Germany in 1951 and marketed in 1952, and has since become available worldwide both as a prescription drug and as an over-the-counter medicine in many countries. | | Uses | Hyoscine butylbromide is an antispasmodic medicine which is taken to relieve cramps in the stomach, intestines or bladder. In particular, it helps to ease bloating and the spasm-type pain that can be associated with irritable bowel syndrome and diverticular disease. It works by relaxing some of the muscles in your gastrointestinal and urinary systems. | | Pharmacokinetics | Pharmacological studies have revealed that hyoscine butylbromide is an anticholinergic drug with high affinity for muscarinic receptors located on the smooth-muscle cells of the GI tract. Its anticholinergic action exerts a smooth-muscle relaxing/spasmolytic effect. Blockade of the muscarinic receptors in the GI tract is the basis for its use in the treatment of abdominal pain secondary to cramping. |
| | Hyoscine Butylbromide Preparation Products And Raw materials |
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