培美曲塞二钠中间体
| 中文名称 | 培美曲塞二钠中间体 |
|---|---|
| 中文同义词 | 培美曲塞酸;二钠培美曲塞;N-[4-[2-(2-氨基-4,7-二氢-4-氧代-3H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰基]-L-谷氨酸;培美曲唑;N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰基]-L-谷氨酸;培美曲塞酸 (N-(4-[2-(2-氨基-4,7-二氢-4-氧-1H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰)-L-谷氨酸);N-[4-[2-(2-胺基-4,7-二氢-4-氧-1H吡咯[2,3-D]嘧啶-5基)乙基]苯甲酰]-L-谷氨酸;培美曲赛杂质1 |
| 英文名称 | Pemetrexed |
| 英文同义词 | PeMetrexed-13C5;PeMetrexed-15C5;N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid);N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid;(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi;N-[4-[2-(2-Amino-4,7;(2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid;N-(4- 2-(2-AMino-4,7-Dihydro-4-oxo-1H-pyrrol... |
| CAS号 | 137281-23-3 |
| 分子式 | C20H21N5O6 |
| 分子量 | 427.41 |
| EINECS号 | 680-625-9 |
| 相关类别 | 原料药;中间体;医药原料;培美中六;小分子抑制剂;Anti-cancer & immunity;医药中间体;细胞凋亡;培美曲塞二钠中间体;药物杂质及中间体;化药杂质-培美曲塞;原料药及中间体;化学试剂;标准品;生物化工;API;CIALIS |
| Mol文件 | 137281-23-3.mol |
| 结构式 |  |
培美曲塞二钠中间体 性质
| 密度 | 1.59±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 微溶于在甲醇中 |
| 形态 | 粉末晶体 |
| 酸度系数(pKa) | 3.58±0.10(Predicted) |
| 颜色 | 白色至蓝色 |
| Merck | 14,7077 |
| CAS 数据库 | 137281-23-3(CAS DataBase Reference) |
Ki: 1.3 nM (TS), 7.2 nM (DHFR), 65 nM (GARFT)
Pemetrexed (LY231514) disodium is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multipie inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. Pemetrexed (LY231514) is one of the best substrates that is known for the enzyme FPGS (K m =1.6 μM and V max /K m =621). It is likely that polyglutamation and the polyglutamated metabolites of LY231514 play profound roles in determining both the selectivity and the antitumor activity of this novel agent. Whereas LY23l5l4 only moderately inhibits TS (K i =340 nM, recombinant mouse), the pentaglutamate of LY23l5l4 is 100-fold more potent (K i =3.4 nM), making LY231514 one of the most potent folate-based TS inhibitors.
The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment.
安全信息
| RTECS号 | LZ9950100 |
|---|---|
| 海关编码 | 2933.99.9701 |
| 毒害物质数据 | 137281-23-3(Hazardous Substances Data) |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-10820 | 培美曲塞二钠盐 Pemetrexed | 137281-23-3 | 10mM * 1mLin DMSO | 770元 |
| 2024/11/08 | HY-10820 | 培美曲塞二钠盐 Pemetrexed | 137281-23-3 | 50mg | 825元 |