诱抗素
| 中文名称 | 诱抗素 |
|---|---|
| 中文同义词 | 5-(1-羟基-2,6,6-三甲基-4-氧-2-环己-1-烯基-3-甲基-2,4-戊二烯酸;脱落素Ⅱ;休眠酸;ABSCISIC ACID 脱落;脱;天然脱落酸,2-顺式,4-反式-5-(1-羟基-4-氧代-2,6,6-三甲基-2-环己烯-1-基)-3-甲基-2,4-戌二烯酸;S-诱抗素;诱抗素 |
| 英文名称 | (+)-Abscisic acid |
| 英文同义词 | (ABA)ABSCISIC ACID >98%;(+)-Abscisic acid;ABA, Dormin, (S)-5-(1-Hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl)-3-methyl-(2Z,4E)-pentadienoic acid;S-(+)-ABA;(S)-(+)-ABSCISIC ACID;[S]-5-[1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYL-[2Z,4E]-PENTADIENOIC ACID;(+)-abscisinii;(+)-cis-abscisicacid |
| CAS号 | 21293-29-8 |
| 分子式 | C15H20O4 |
| 分子量 | 264.32 |
| EINECS号 | 244-319-5 |
| 相关类别 | 植物生化提取物;小分子抑制剂，天然产物;植物激素及核酸类;植物生长激素;营养学研究;生化试剂;对照品;医药原料药-科研原料;plantgrowth;农用原药-原药;有机原料;高纯生化试剂;生化试剂-植物激素及核酸类;农用化学品原料;原料;农药;化妆品原料;其他原料;化学试剂;化工原料;科研精品试剂;其它;有机化工原料;生物缓冲液系列;Pharmaceutical Raw Materials;Sesqui-Terpenoids;Chiral Reagents;Biochemistry;Plant Growth Regulators;Plant Growth Trgulators (Others);Plant Hormones;Agro-Products;Inhibitors;Plant Growth regulator |
| Mol文件 | 21293-29-8.mol |
| 结构式 |  |
诱抗素 性质
| 熔点 | 188 °C |
|---|---|
| 比旋光度 | D20 +411.1° (c = 1 in ethanol); D20 +426.5° (c = 1 in 0.005N methanolic H2SO4) |
| 沸点 | 327.55°C (rough estimate) |
| 密度 | 1.0583 (rough estimate) |
| 折射率 | 410 ° (C=0.2, EtOH) |
| 储存条件 | 2-8°C |
| 溶解度 | 氯仿（微溶）、乙醇（微溶）、甲醇（微溶） |
| 酸度系数(pKa) | 4.87±0.33(Predicted) |
| 形态 | 类白色粉末 |
| 颜色 | 白色至浅黄色 |
| 旋光性 (optical activity) | [α]/D 415±10°, c = 0.1 in ethanol |
| Merck | 14,11 |
| BRN | 2698956 |
| 稳定性 | 感光 |
| InChIKey | JLIDBLDQVAYHNE-WEYXYWBQSA-N |
| LogP | 1.896 (est) |
| CAS 数据库 | 21293-29-8(CAS DataBase Reference) |
| EPA化学物质信息 | 2,4-Pentadienoic acid, 5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl]-3-methyl-, (2Z,4E)- (21293-29-8) |
(+)-脱落酸纯品为无色晶体。熔点160~161℃。120℃升华，分配系数为1.8(电中性形式)、0.94(离子形式)。相对密度1.21。在水中的溶解度为3102mg/L(pH 4)。旋光率[a]20D = +409.97R(20℃在乙醇中,10.1mg/mL)。pKa为4.61。溶于氯仿、丙酮、乙酸乙酯和乙醚。微溶于苯和水。紫外最大吸收波长(甲醇)252nm。
大鼠急性经口LD50 >5000mg/kg。大鼠急性经皮LD50>5000mg/kg。大鼠吸入LC50(4h)>5.1mg/L。NOEL:(90d)大鼠每天2000mg/L;(3周)大鼠经皮1000mg/kg; NOAEL1000mg/(kg·d)。
(+)-脱落酸是一种植物生长调节剂，具有诱导植物休眠、抑制种子萌发和植物生长、刺激气孔关闭等多方面的生理作用。
(+)-脱落酸通过如下反应制得：
|
Human Endogenous Metabolite
|
In Arabidopsis cell cultures, Abscisic acid ((S)-(+)-Abscisic acid; 10 μM) simultaneously induces rapid alkalinization of the medium and plasma membrane depolarization.
Abscisic acid (10 μM) increases Ca
2+
in cytosol of Arabidopsis cell suspension. Abscisic acid does not inhibit proton pumping directly but through an increase in cytosolic Ca
2+
.
Lanthionine synthetase C-like 2 (LANCL2) is the natural receptor for Abscisic acid. Abscisic acid, both at the organism levels and in specific muscle cells ex vivo, increases both glucose and fatty acid metabolism in the mitochondria, increases glycogen synthesis, activates PI3K independently of insulin and promotes GLUT4 translocation to the cell membrane.
Abscisic acid (orally; 0.125 µg/kg/day; for 12 weeks) improves glycemic control.
Abscisic acid (orally; 0.125 µg/kg/day; for 12 weeks) results in significantly lower levels of TNF, MCP-1 and IL-6 in the DIO model. Abscisic acid increases metabolic activity in skeletal muscle.
| Animal Model: | Diet-induced obesity (DIO) mice at 4 weeks of age |
| Dosage: | 0.125 µg/kg |
| Administration: | Orally; daily; for 12 weeks |
| Result: | Improved glycemic control in a diet-induced model of obesity |
| 提供商 | 语言 |
|---|---|
|
英文
|
|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/11 | XW212932986 | (+)-脱落酸 | 21293-29-8 | 100MG | 93元 |
| 2024/11/11 | XW212932985 | (+)-脱落酸 | 21293-29-8 | 50MG | 60元 |