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| N-Methyl-1H-Indole-5-EthaneSulphonamide Basic information |
Product Name: | N-Methyl-1H-Indole-5-EthaneSulphonamide | Synonyms: | N-Methyl-1H-Indole-5-EthaneSulphonamide;N-Methyl-1H-indole-5-ethanesulfonamide;2-(1H-indol-5-yl)-N-MethylethanesulfonaMide;N-Methyl-1H-indole-5-ethanesulfonamide, >=98%;N-Methyl-1H-Indole-5-EthaneSulphomide;1H-Indole-5-ethanesulfonamide, N-methyl-;2 - (1h-indole-5-yl) - n-methylethyl-1-sulfonamide;2-(1H-indol-5-yl)-N-methylethane-1-sulfonamide | CAS: | 98623-50-8 | MF: | C11H14N2O2S | MW: | 238.31 | EINECS: | 1592732-453-0 | Product Categories: | | Mol File: | 98623-50-8.mol | |
| N-Methyl-1H-Indole-5-EthaneSulphonamide Chemical Properties |
Melting point | 124-125°C | Boiling point | 458.4±47.0 °C(Predicted) | density | 1.316±0.06 g/cm3(Predicted) | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | 11.52±0.40(Predicted) | color | White to Off-White |
| N-Methyl-1H-Indole-5-EthaneSulphonamide Usage And Synthesis |
Uses | N-Methyl-1H-indole-5-ethanesulfonamide is used as a reagent in the synthesis of Naratriptan Hydrochloride (N378730); a triptan drug used for the treatment of migraine headaches. | General Description | N-Methyl-1H-Indole-5-EthaneSulphonamide, also known as 2-(1H-Indol-5-yl)-N-methylethanesulfonamide, is a white solid. | Synthesis | At 40-45 ℃ (hydrogen pressure: 3-4 kg/cm2), 2-(3-Phenylsulf-anyl-1H-indol-5-yl)-ethanesulfonic acidmethylamide (14) (5 g, 0.014 mol) was hydrogenated in ethanol: water (7:3) (40 ml) in an autoclave for 10 h. After that, the reaction mass was cooled to room temperature, followed by removing the catalyst through filtering. The filtrate was distilled out to get N-Methyl-1H-Indole-5-EthaneSulphonamide. |
| N-Methyl-1H-Indole-5-EthaneSulphonamide Preparation Products And Raw materials |
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