四氢姜黄素
中文名称 | 四氢姜黄素 |
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中文同义词 | TETRAHYDROCUCUMIN 四氢姜黄素;四氢姜黄素;1,7-双(4-羟基-3-甲氧基苯基)庚烷-3,5-二酮;纳米包裹辅酶四氢姜黄素;生物活性四氢姜黄素;水溶性四氢姜黄素;7-双(4-羟基-3-甲氧基苯基)庚烷-3;四氢姜黄素(标准品) |
英文名称 | Tetrahydrocurcumin |
英文同义词 | 1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione;Tetrahydrocurcumin;TETRAHYDROCURCUMINOID;Aids110028;Aids-110028;Nsc687845;TETRAHYDROCURCUMIN(P);TetrahydrocucuMin |
CAS号 | 36062-04-1 |
分子式 | C21H24O6 |
分子量 | 372.41 |
EINECS号 | 609-201-3 |
植物来源 | 姜黄 |
相关类别 | 香精香料;标准品;植物提取物;中药对照品;对照品;四氢姜黄素;原料药API;日化美白原料;中间体;标准品-对照品;其他原料;原料;化妆品原料;对照品-中药对照品;其它酚类;标准品 -中药标准品;标准品,对照品;化工原料;合成材料中间体;医药、农药及染料中间体;色素;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;标准提取物;标准提取物;化学试剂 |
Mol文件 | 36062-04-1.mol |
结构式 |
四氢姜黄素 性质
熔点 | 95-97 ºC |
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沸点 | 564.1±45.0 °C(Predicted) |
密度 | 1.222 |
闪点 | 196℃ |
储存条件 | Inert atmosphere,Room Temperature |
溶解度 | 可溶于DMSO(轻微)、甲醇(轻微、加热) |
酸度系数(pKa) | 9.12±0.10(Predicted) |
形态 | 粉末 |
颜色 | 浅黄色至厚黄色 |
BRN | 3485469 |
稳定性 | 感光 |
InChI | InChI=1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3 |
InChIKey | LBTVHXHERHESKG-UHFFFAOYSA-N |
SMILES | C(C1=CC=C(O)C(OC)=C1)CC(=O)CC(=O)CCC1=CC=C(O)C(OC)=C1 |
LogP | 2.728 (est) |
四氢姜黄素为天然的姜黄根提取物中主要的美白活性成分,不仅具有最强的酪氨酸酶抑制活性,还具有极好的化学稳定性,而且外观为无味的白色粉末,从而克服了普通姜黄提取物化学不稳定易使皮肤染色的缺陷。普通的姜黄提取物为黄色,化学稳定性差,具有光敏性,在光照下,容易和皮肤发生化学反应而使皮肤染色。四氢姜黄素为天然功能性美白原料,具有抑制酪氨酸酶的强效活性,美白效果优于我们熟知的熊果苷,能有效抑制氧自由基(oxygen free radicals)的生成并能清除已经形成的自由基,具有明显的抗氧化、抑制黑色素、修复祛斑、抗炎活性、阻断炎症过程等。此外,对自由基的抑制、对各种炎因子脂氧和酶、胶原蛋白酶、透明质酸酶的抑制,体现了四氢姜黄素潜在的抗衰老功效。四氢姜黄素添加到化妆品中对人体肌肤无刺激或致敏的副作用,且能安全有效地发挥其作用。Tetrahydrocurcumin 在姜黄 (Curcuma longa) 中发现的一种姜黄素,是由 Curcumin 还原产生的。Tetrahydrocurcumin 抑制 CYP2C9 和 CYP3A4。
CYP2C9
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CYP3A4
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Human Endogenous Metabolite
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Autophagy
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Tetrahydrocurcumin (THC) has a number of attractive properties not shared with Curcumin that may make it superior. Tetrahydrocurcumin inhibited lipoxygenase as low as 1 μM. Tetrahydrocurcumin is tested for its ability to inhibit CYP2C9, CYP3A4, CYP1A2 and CYP2D6. Tetrahydrocurcumin yields dose-dependent inhibition of CYP2C9, and to a lesser extent, CYP3A4. Tetrahydrocurcumin exhibits maximum inhibition of CYP2C9 and CYP3A4 at 50 to 100 μM. Tetrahydrocurcumin does not show a consistent dose-response inhibition of CYP1A2 or CYP2D6 over the range of concentrations tested. In some cases, the percent inhibition exceeds 100%. The effect of Tetrahydrocurcumin on cancer cell viability is measured. Sup-T1 cells, T-cell lymphoblastic lymphoma cells, are treated with Tetrahydrocurcumin to determine its ability to induce growth inhibition using an MTS assay, and the corresponding IC50 values are in the mid-to-high micromolar range.
The serum Tetrahydrocurcumin (THC) concentration versus time curve shows that more than one absorption and distribution phase is present. Initially, a rapid absorption phase with an average Tmax of 6.8 μg/mL at 1 h is observed, followed by a short elimination phase. This is followed by two redistributions with two smaller Tetrahydrocurcumin maxima at 6 and 24 h. Both redistribution phases has similar maxima of about 1 μg/mL. The total amount of Tetrahydrocurcumin excrets unchanged in urine was up to 8 μg at 24 h.
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0893 | 四氢姜黄素 Tetrahydrocurcumin | 36062-04-1 | 5mg | 500元 |
2024/08/19 | HY-N0893 | 四氢姜黄素 Tetrahydrocurcumin | 36062-04-1 | 10mM * 1mLin DMSO | 550元 |