噻前列素
| 中文名称 | 噻前列素 |
|---|---|
| 中文同义词 | 噻前列素71116-82-0,工厂零售71116-82-0;7-[3,5-二羟基-2-[3-羟基-4-(3-噻吩氧基)-1-丁烯基]环戊基]-5-庚烯酸;噻前列素;化合物 T17092;7-(3,5-二羟基-2-(3-羟基-4-(噻吩-3-基氧基)丁-1-烯-1-基)环戊基)庚-5-烯酸 |
| 英文名称 | Tiaprost |
| 英文同义词 | Tiaprost;7-[3,5-Dihydroxy-2-[3-hydroxy-4-(3-thienyloxy)-1-butenyl]cyclopentyl]-5-heptenoic acid;Tiaprost(Iliren);(E)-7-[3,5-dihydroxy-2-[(E)-3-hydroxy-4-thiophen-3-yloxybut-1-enyl]cyclopentyl]hept-5-enoic acid;FYBFDIIAPRHIQS-JRSBLEPXSA-N;Tiaprost Exclusive;5-Heptenoic acid, 7-[3,5-dihydroxy-2-[3-hydroxy-4-(3-thienyloxy)-1-buten-1-yl]cyclopentyl]-;Iliren |
| CAS号 | 71116-82-0 |
| 分子式 | C20H28O6S |
| 分子量 | 396.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 71116-82-0.mol |
| 结构式 |  |
噻前列素 性质
| 沸点 | 613.4±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.325±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：30mg/mL； PBS（pH 7.2）：2 mg/mL |
| 形态 | 液体 |
| 酸度系数(pKa) | 4.79±0.10(Predicted) |
| 颜色 | 无色至浅黄 |
|
PGF 2α
|
Plasma progesterone levels decrease sharply within 12 hours after the initial treatment with Tiaprost and within 24 hours reach levels at about 3.18 nM (1 ng/mL). Over the following days, progesterone levels remain either slightly above (cows 1, 3, 5 and 6) or below (cow 2) 3.18 nM. In cow 4, levels remain for 17 days above 3.18 nM and drop below this level thereafter. At term, all cows show the lowest recorded progesterone levels (1 to 2 nM). Repeated luteolytic treatments with Tiaprost (cows 1 and 2) or estradio1 benzoate (cow 3) has no further influence on individual progesterone levels. Treatment with progesterone-releasing intravaginal device (PRID) does not significantly elevate progesterone plasma levels. Total estrogens in plasma remained in general unchanged.
安全信息
| 危险品运输编号 | 3249 |
|---|---|
| 危险等级 | 6.1(b) |
| 包装类别 | III |