124900-72-7
| 中文名称 | 124900-72-7 |
|---|---|
| 中文同义词 | 化合物 T13373;化合物YM17E;1,1'-(1,3-亚苯基双(亚甲基))双(1-环庚基-3-(4-(二甲基氨基)苯基)脲);1,1'-(1,3-亚苯基双(亚甲基))双(1-环庚基-3-(4-(二甲基氨基)苯基)脲) |
| 英文名称 | YM17E |
| 英文同义词 | YM17E;Urea, N,N''-[1,3-phenylenebis(methylene)]bis[N-cycloheptyl-N'-[4-(dimethylamino)phenyl]- (9CI);Diglyceride acyltransferase,Inhibitor,acyl-CoA:cholesterol acyltransferase,inhibit,YM17E,Acyltransferase,Diacylglycerol acyltransferase,mono- acylglycerol acyltransferase,YM-17E;1,1'-(1,3-Phenylenebis(methylene))bis(1-cycloheptyl-3-(4-(dimethylamino)phenyl)urea);1,1'-(1,3-Phenylenebis(methylene))bis(1-cycloheptyl-3-(4-(dimethylamino)phenyl)urea) |
| CAS号 | 124900-72-7 |
| 分子式 | C40H56N6O2 |
| 分子量 | 652.93 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 124900-72-7.mol |
| 结构式 |  |
124900-72-7 性质
| 沸点 | 862.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.16±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.03±0.70(Predicted) |
| 颜色 | 白色至米白色 |
IC50: 44 nM (ACAT in rabbit liver microsomes)
YM17E is as potent in inhibiting ACAT activity in the liver as in the intestine, with IC 50 values of 45 and 34 nM, respectively.
YM17E (3, 10 and 30 mg/kg per day, p.o.) decreases total cholesterol, cholesteryl ester and non-HDL cholesterol in a dose-dependent manner. Total cholesterol and cholesteryl ester levels in liver do not decrease significantly after intravenous administration of YM17E, but do decrease significantly and in a dose-dependent manner after oral administration. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E produces a significant increase in 125 I-LDL clearance in atherogenic diet-fed rats after both oral and intravenous administration. YM17E inhibits production of [ 14 C]cholesteryloleate from [ 14 C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-101627 | 124900-72-7 YM17E | 124900-72-7 | 1mg | 380元 |
| 2024/08/19 | HY-101627 | YM17E | 5 mg | 780元 |