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| | TIN PROTOPORPHYRIN IX DICHLORIDE Basic information |
| Product Name: | TIN PROTOPORPHYRIN IX DICHLORIDE | | Synonyms: | tin protoporphyrin IX;TINPROTOPORPHYRIN;Nsc267099;Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid];Tin Protoporphyrin IX (chloride);TIN PROTOPORPHYRIN IX DICHLORIDE;SnPPIX;Tin protoporphyrin I | | CAS: | 14325-05-4 | | MF: | C34H36Cl2N4O4Sn | | MW: | 754.29 | | EINECS: | | | Product Categories: | Porphyrins | | Mol File: | 14325-05-4.mol |  |
| | TIN PROTOPORPHYRIN IX DICHLORIDE Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble to 25 mM in 1eq. NaOH and to 5 mM in DMSO | | form | Dark red to violet solid. |
| | TIN PROTOPORPHYRIN IX DICHLORIDE Usage And Synthesis |
| Uses | Tin Protoporphyrin IX Dichloride is a selective inhibitor of heme oxygenase. | | Uses | Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. TIN PROTOPORPHYRIN IX DICHLORIDE(SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.[Cayman Chemical] |
| | TIN PROTOPORPHYRIN IX DICHLORIDE Preparation Products And Raw materials |
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