| Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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| Tel: |
021-51320588 |
| Email: |
tauto@tautobiotech.com |
| Products Intro: |
Product Name:Reticulol
CAS:26246-41-3
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:BVT-0011-M001
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| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Basic information |
| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Chemical Properties |
| Melting point | 193-193.5℃ | | Boiling point | 473.2±45.0 °C(Predicted) | | density | 1.424±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 7.19±0.20(Predicted) | | form | A powder | | color | White to off-white |
| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Usage And Synthesis |
| Description | Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 μM). It also inhibits DNA topoisomerase I when used at a concentration of 45 μM in B16F10 melanoma cells. Reticulol has antifungal activity against T. mentagrophyes with a MIC of 1.8 μM. It is cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 μM, respectively, and inhibits lung metastasis in mice. | | Uses | Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I. | | Uses | Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model. | | storage | +4°C |
| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Preparation Products And Raw materials |
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