4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐
| 中文名称 | 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 |
|---|---|
| 中文同义词 | 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐;化合物LY 334370;4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺 |
| 英文名称 | LY 334370 HYDROCHLORIDE |
| 英文同义词 | LY 334370 HYDROCHLORIDE;4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide;BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-;4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate;LY-334370 hydrochloride hydrate;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide hydrochloride |
| CAS号 | 182563-08-2 |
| 分子式 | C21H22FN3O |
| 分子量 | 351.42 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 182563-08-2.mol |
| 结构式 |  |
4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 性质
| 沸点 | 479.1±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.267±0.06 g/cm3(Predicted) |
| 储存条件 | Store at +4°C |
| 溶解度 | 在水中的溶解度为≥5mg/mL（加热） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.98±0.43(Predicted) |
| 颜色 | 白色至棕褐色 |
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5-HT 1F Receptor 1.6 nM (Ki) |
LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10 -5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant.
Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se , since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg).
安全信息
| WGK Germany | 3 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-103107 | 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 LY334370 | 182563-08-2 | 5mg | 800元 |
| 2024/04/30 | HY-103107 | 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐 LY334370 | 182563-08-2 | 10mM * 1mLin DMSO | 880元 |