曲索罗地
| 中文名称 | 曲索罗地 |
|---|---|
| 中文同义词 | (1S,2S)-1-[4-羟苯基]-2-(4-羟基-4-苯哌啶基)-1-丙醇;崔索普地;曲索罗地 INTG;曲索罗地;1-((1S,2S)-1-羟基-1-(4-羟基苯基)丙烷-2-基)-4-苯基哌啶-4-醇;TRAXOPRODIL (CP101,606),NMDA 拮抗剂 |
| 英文名称 | (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL |
| 英文同义词 | 1-((1S,2S);-1-Hydroxy-1-(4-hydroxyphenyl);propan-2-yl);(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL;CP 101606;1-[(1S,2S)-2-Hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-4-phenylpiperidin-4-ol;(1s,2s)-1-[4-[ hydroxylphenyl]- 2- ( 4-hydroxy-4-pheny1piperidino)-1- propanol;1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol |
| CAS号 | 134234-12-1 |
| 分子式 | C20H25NO3 |
| 分子量 | 327.42 |
| EINECS号 | |
| 相关类别 | 原料药 |
| Mol文件 | 134234-12-1.mol |
| 结构式 |  |
曲索罗地 性质
| 沸点 | 534.4±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.228 |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥35mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 9.99±0.26(Predicted) |
| 颜色 | 白色至棕褐色 |
| 旋光性 (optical activity) | [α]/D +50 to +60° (c=1, MeOH) |
CP-101,606 已被用作N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂，以研究其在脊髓损伤恢复中的作用。
Traxoprodil (CP101,606) 是一种有效的和选择性的 NMDA 拮抗剂，保护海马神经元的 IC50 值为10 nM。IC50: 10 nM (Neuroprotection)
Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED 50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-W018061 | Traxoprodil | 1 mg | 300元 | |
| 2024/01/25 | HY-W018061 | 曲索罗地 Traxoprodil | 134234-12-1 | 5mg | 750元 |